alexa Plasma Hemoxygenase-1 and Cardiac Enlargement in Chronic Heart Failure Patients | OMICS International
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Plasma Hemoxygenase-1 and Cardiac Enlargement in Chronic Heart Failure Patients

J. Georgieva1* and K. Vitlianova2
1Associate Professor, Chief Department of Internal Medicine and Clinic of Cardiology, University Hospital St Marina, Medical University of Varna, Bulgaria
2Assistant professor, Department of Internal Medicine, Clinic of Cardiology, University Hospital Alexandrovska, Medical University of Sofia, Bulgaria
Corresponding Author : J. Georgieva
Associate Professor
Chief Department of Internal Medicine and Clinic of Cardiology University Hospital St Marina
Medical University of Varna, Varna 9000, Bulgaria
Tel: +359 888 611 367
E-mail: [email protected]
Received: December 07, 2011; Accepted: January 11, 2012; Published: January 18, 2012
Citation: Georgieva J, Vitlianova K (2012) Plasma Hemoxygenase-1 and Cardiac Enlargement in Chronic Heart Failure Patients. J Clinic Experiment Cardiol S2:003. doi:10.4172/2155-9880.S2-003
Copyright: © 2012 Georgieva J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Introduction: Heme oxygenase-1 (HO-1) is a stress protein that is involved in protection of cardiac diaseases from diffrent noxious stimuli. Objective: We investigated whether plasma HO-1 is changed in cronic heart failure (CHF) patients and whether plasma HO-1measurements provide a peripheral biomarker of the disease. Methods: Plasma HO-1, were measured in 24 normal controls (NEC) and in 53 consecitive patients with CHF admitted to the Clinic of Cardiology over the period May 2010 - January, 2011. Systolic dysfunction was defined at left ventricle ejection fraction (LVEF) < 40%. Standardised protocol was used for colecting information on the investigated variables of interest. Plasma HO-1 and Brain natriuretic peptide (BNP) were measured with immunoassays. Depending on the distribution variables are reported with mean and median. Аssociations of the variables with HO-1 were investigated with linear regression analyses. Results: Plasma HO-1 concentrations (ng/ml) were significantly lower in CHF patients (median 2.58, range 0.5-7.3) compared with NEC (median 5.2 range 1.2-12.2) (p < 0.01). Circulating BNP levels were not significantly correlated with plasma HO-1 levels. There was a significant negative correlation between HO1 and serum total bilirubin (p<0.05). A negative weak correlations were also observed with functional class (p<0.05) and atrial fibrillation (p<0.05). Plasma levels of HO-1 showed a significant considerable positive correlation with left ventricle (LV) dimensions values. Independent predictive effects on HO-1 levels in multiple regression analysis (F=8.2, p<0.01) were explored for the values of the LV end-diastolic volume and artrial fibrillation. Conclusion: Plasma HO-1 are decreased in patients with CHF. Levels of HO-1 are independently correlated to the degree of cardiac enlargement. Further studies are needed on the concrete mechanisms of the deranged HO-1 regulation in CHF patients.

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