Plasma Phenytoin Levels and Incidence of Seizure in Patients Undergoing Craniotomy for Supratentorial Brain Tumors
Aitsaraporn Phunsawat*, Lawan Tuchinda and Wanna Somboonviboon
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Chulalongkorn Hospital, Thailand
- *Corresponding Author:
- Phunsawat A
Department of Anesthesiology
Faculty of Medicine, Naresaun University
Phitsanulok 65000, Thailand
E-mail: [email protected]
Received date: July 17, 2012; Accepted date: October 17, 2012; Published date: October 27, 2012
Citation: Phunsawat A, Tuchinda L, Somboonviboon W (2012) Plasma Phenytoin Levels and Incidence of Seizure in Patients Undergoing Craniotomy for Supratentorial Brain Tumors. J Anesth Clin Res 3:255 doi: 10.4172/2155-6148.1000255
Copyright: © 2012 Phunsawat A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Phenytoin is often used to prevent seizures especially postoperative seizures after craniotomy for supratentorial brain tumors but the effectiveness is controversy. To investigate perioperative changes in plasma phenytoin levels and incidence of immediate postoperative seizure in patients undergoing craniotomy for supratentorial brain tumors. The study is prospective observational descriptive study. Twenty patients who received phenytoin and undergoing craniotomy for supratentorial brain tumors were enrolled in this study. The measurement of plasma phenytoin levels were done at preoperative, intraoperatively and postoperative period after the second dose of phenytoin. Demographic data of the patients were recorded include age, sex, weight, preoperative seizure, pathology, size and location of brain tumors, operative duration, amount of fluid replacement and blood loss. If postoperative seizure occurred, plasma phenytoin level was measured again.