Plasticity of Th17 cells and therapeutic conundrum
Institut National de la Santé et de la Recherche Médicale, Unité 872, 15 rue de l’Ecole de Médicine, Paris, F-75006, France, Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and therapeutic immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 872, Paris, F-75006, France, Université Paris Descartes, UMR S 872 Paris, F-75006, France, International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohaemotology, Mumbai, India
- *Corresponding Author:
- Jagadeesh Bayry
Institut National de la Santé et de la Recherche Médicale Unité
Equipe 16-Centre de Recherche des Cordeliers
15 rue de l’Ecole de Médicine, Paris, F-75006, France
Tel: 00 33 1 44 27 82 03/81 93
Fax: 00 33 1 44 27 81 94
E-mail: [email protected]
Received date: December 13, 2011; Accepted date: December 14, 2011; Published date: December 15, 2011
Citation: Bayry J (2011) Plasticity of Th17 cells and therapeutic conundrum. J Blood Lymph 1:e101. doi:10.4172/2165-7831.1000e101
Copyright: © 2011 Bayry J . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
CD4+ T cells are highly heterogeneous with respect to their phenotype, secretion of effector molecules, transcription factors and functions. In the periphery, CD4+ T cells can be polarized into distinct subsets under the influence of antigen presenting cells and cytokine milieu. Recently, Th17 cells that express lineage-specific transcription factor RORC (ROR?t in mice) and produce cytokines IL-17A and IL-17F were identified as distinct lineage of CD4+ T cells . Th17 cells are important to clear extracellular bacteria and fungi. However, when tolerance mechanisms breach, these Th17 cells can also mediate inflammation and can play critical role in the pathogenesis of several autoimmune diseases. In fact, a large number of autoimmune and inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, asthma, lupus, psoriasis and others are characterized by an aberrant activation of Th17 cells and hyper-expression of Th17 inflammatory mediators such as IL-17, IL-21, IL-22, CCL20 and GM-CSF [2,3]. Therefore, Th17 cells are one of the potential targets to treat these diseases.