Platelet Activation as a Possible Indicator of Disease Activity in Chronic Urticaria: Link with Blood Coagulation and Mast Cell Degranulation
Ichiro Katayama*, Saki Matsui and Hiroyuki Murota
Department of Dermatology Integrated Medicine, Graduate School of Medicine, Osaka University, Japan
- *Corresponding Author:
- Ichiro Katayama
Department of Dermatology Integrated Medicine
Graduate School of Medicine
Osaka University.2-2 Yamada-oka
Suitashi, Osaka, Japan 565-0871
E mail: [email protected]
Received date: October 18, 2013; Accepted date: November 09, 2013; Published date: November 16, 2013
Citation: Katayama I, Matsui S, Murota H (2013) Platelet Activation as a Possible Indicator of Disease Activity in Chronic Urticaria: Link with Blood Coagulation and Mast Cell Degranulation. J Clin Exp Dermatol Res 4:194. doi: 10.4172/2155-9554.1000194
Copyright: © 2013 Jung YG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Much attention has been paid to activation of the blood coagulation cascade during urticaria attacks. Elevated levels of plasma D-dimer and prothrombin fragment 1+2 have been reported. The final product of the coagulation cascade, thrombin, may induce mast cell degranulation, complement fragmentation, or platelet-activating factor expression. However, the involvement of platelets in urticaria is poorly understood.
Methods: We examined the relationship between disease activity and plasma levels of platelet factor IV, β-thromboglobulin, D-dimer, and prothrombinfragment (Fr) 1+2 in 23 patients with chronic urticaria.
Results: We observed elevated plasma levels of platelet factor IV (13/23) and β-thromboglobulin (15/23) in patients with chronic urticaria that returned to normal after anti-histamine therapy. Platelet re-activation was observed in recurrent urticaria. Some cases showed clinical response to anti-platelet therapy or Helicobacter pylori decolonization in combination with anti-histamine treatment.
Conclusions: Platelet activation is a possible indicator of disease activity in chronic urticaria. Platelet-derived factors with or without blood coagulation products might induce mast cell degranulation in chronic urticaria.