alexa Platelet Function Disorders in Adolescents with Heavy Menstrual Bleeding: Clinical Presentations, Laboratory Testing and Treatment Options
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Review Article

Platelet Function Disorders in Adolescents with Heavy Menstrual Bleeding: Clinical Presentations, Laboratory Testing and Treatment Options

Lawrence S Amesse1*, James A French2 and Teresa Pfaff-Amesse1

1Section of Pediatric/Adolescent Gynecology, Atlantic Reproductive Associates, Boynton Beach, Florida, USA

2Division of Hematology and Oncology, Department of Pediatrics, Dayton Children’s Hospital, Dayton, Ohio, USA

*Corresponding Author:
Lawrence S Amesse
Atlantic Reproductive Associates
10301 Hagen Ranch Road, Suite 6
Boynton Beach, Florida 33437, USA
Tel: 937-545-2011
Fax: 937-458-5005
E-mail: [email protected]

Received date: September 24, 2013; Accepted date: December 24, 2013; Published date: December 29, 2013

Citation: Amesse LS, French JA, Pfaff-Amesse T (2013) Platelet Function Disorders in Adolescents with Heavy Menstrual Bleeding: Clinical Presentations, Laboratory Testing and Treatment Options. J Blood Disord Transfus 5:186. doi: 10.4172/2155-9864.1000186

Copyright: © 2013 Amesse LS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Platelet Function Disorders (PFD) is receiving increasing attention as an important etiology of Heavy Menstrual Bleeding (HMB) in adolescents. An understanding of presentation profiles, diagnostic limitations and effective treatment regimens for these disorders are important for effective management of these disorders. Methods: This study reviews the literature on the diagnosis and treatment of platelet function disorders in adolescents with heavy menstrual bleeding. Results: Heavy menstrual bleeding affects the quality of life of many adolescents, and PFDs appearing to be an important underlying etiology of this disorder. The storage pool subtype is the most prevalent of the platelet functional defects in these patients. Standard platelet functions screening has a number of limitations in diagnosing many of the PFD subtypes, and platelet aggregation studies and electron microscopy are important diagnostic adjuncts. Hormonal and non-hormonal treatment regimens are available and treatment recommendations will depend on the severity of bleeding. Conclusion: Clinicians treating adolescent with HMB should be aware of PFDs and the diagnostic limitations in detecting many of the subtypes. Management depends on the severity of bleeding.


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