Platelet Transfusion; What and When to Transfuse, a Dilemma of Clinical Practice
|Tasnim Ahsan, Rukhshanda Jabeen, Urooj Lal Rehman*, Zeenat Banu and Samar Abbas Jaffri|
|Medical Unit II, JPMC Karachi, Pakistan|
|*Corresponding Author :||Urooj Lal Rehman
Senior Registrar, Medical Unit II
JPMC Karachi, Pakistan
E-mail: [email protected]
|Received September 11, 2014; Accepted January 05, 2015; Published January 12, 2015|
|Citation: Ahsan T, Jabeen R, Rehman UL, Banu Z, Jaffri SA (2015) Platelet Transfusion; What and When to Transfuse, a Dilemma of Clinical Practice. Intern Med 5:181. doi:10.4172/2165-8048.1000181|
|Copyright: © 2015 Ahsan T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: To evaluate the effectiveness of guidelines driven platelet transfusion as well as to compare effectiveness of low verses high dose of the platelets transfusion.
Study design: Observational chart analysis study.
Place and duration of study: Jinnah Post Graduate Medical Center, Medical unit II, for 2 years in 2011 (Study- A) and 2012 (Study-B).
Material and method: Study A included 130 and Study B included 111 patients. In Study-A, retrospective chart analysis was done for all the patients who were either bleeding or had low platelet counts. Platelet transfusions given to these patients were evaluated. Based on these results and WHO bleeding stages; guidelines were structured for futures platelet transfusion. In Study B platelet transfusion were driven by these guidelines. Outcomes in form of discharge and death of patients given low, medium and high dose platelets were compared.
Results: In Study A; 98 patients were transfused platelets, out of which only 76 were actively bleeding; while in Study B platelets were transfused in 65 patients of whom 62 patients were having active bleeding. The outcome in term of patient discharged and expired was seen to be comparable in different dosage groups with a significant P value <0.005.
Conclusion: After following guidelines, 1% inappropriate platelet transfusions were administered as compared to 20% inappropriate transfusions in previous year. Low dose platelets were as effective as high dose platelets.