alexa Platelet-Activity Dependence on the Age of Rats with Experimental Dyslipidemia
ISSN: 0974-8369

Biology and Medicine
Open Access

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Research Article

Platelet-Activity Dependence on the Age of Rats with Experimental Dyslipidemia

Zavalishina SYu1*, Kutafina NV1,2, Vatnikov YuA3, Makurina ON4, Kulikov EV3, Rystsova EO3, Gurina RR3 and Sotnikova ED3

1Kursk Institute of Social Education, Russian State Social University, 53 K. Marx Street, 305029 Kursk, Russia

2All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals, Institute of village, 249013, Borovsk, Russia

3Veterinary Faculty, Peoples’ Friendship University of Russia, b.6, Miklukho-Maclay street, 117198, Moscow, Russia

4Department of Biology, Samara State Aerospace University named after academician S.P.Korolev (National Research University), b.34, Moscow highway, 443086 Samara, Russia

*Corresponding Author:
Zavalishina SYu
Kursk Institute of Social Education
Russian State Social University
53 K. Marx Street, 305029 Kursk, Russia
E-mail: [email protected]

Received Date: April 18, 2016; Accepted Date: July 29, 2016; Published Date: August 23, 2016

Citation: Zavalishina SYu, Kutafina NV, Vatnikov YuA, Makurina ON, Kulikov EV, et al. (2016) Platelet-Activity Dependence on the Age of Rats with Experimental Dyslipidemia. Biol Med (Aligarh) 8:326. doi:10.4172/0974-8369.1000326

Copyright: © 2016 Zavalishina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium provided the original author and source are credited.



The purpose of the paper is to reveal the dependence of platelet activity level in rats on the age of their experi- mental dyslipidemia. The study included 105 healthy male rats (34 rats aged 12 months, 32 rats aged 18 months, and 39 rats aged 24 months) with modeled dyslipidemia. The control group included 91 healthy male rats (30 animals aged 12 months, 32 rats aged 18 months, and 29 animals aged 24 months) under standard vivarium conditions. Biochemical, hematological, and statistical methods were applied. Gradual increasing of functional platelet activity was noticed in the control rats with increasing age. Alimentary modeling of dyslipidemia in the rats resulted in marked platelet-activity increase, growing with the increase in the experimental animals’ age. Dyslipidemia modeling in the rats of different age showed the weakening of plasma antioxidant protection and increase in plasma LPO, deepening with the increase in the studied animals’ age. The developing disorders in the experimental rats exceeded the age-related changes of platelet activity in the control.


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