alexa Platelet-Rich Plasma in Temporomandibular Joint Osteoar
ISSN: 2167-7921

Journal of Arthritis
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Research Article

Platelet-Rich Plasma in Temporomandibular Joint Osteoarthritis Therapy: A 3-Month Follow-Up Pilot Study

Vladimir Machoň1*, Monika Řehořová1, JiÅ™í Šedý1,2 and René Foltán1
1Department of Oral Maxillofacial Surgery, General University Hospital, Prague, Czech Republic
2Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Corresponding Author : Vladimír Machon
Department of Oral Maxillofacial Surgery
General University Hospital, Prague
U Nemocnice 2, 120 00, Prague, Czech Republic
Tel: +420-721151540
E-mail: [email protected]
Received September 06, 2013; Accepted October 17, 2013; Published October 24, 2013
Citation: Machon V, Rehorová M, Šedý J, Foltán R (2013) Platelet-Rich Plasma in Temporomandibular Joint Osteoarthritis Therapy: A 3-Month Follow-Up Pilot Study. J Arthritis 2:112. doi:10.4172/2167-7921.1000112
Copyright: © 2013 Machon V W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The use of Platelet-Rich-Plasma (PRP) may provide a new and improved treatment option for early Temporomandibular Joint (TMJ) Osteoarthritis (OA). However, there are no studies on its use in TMJ arthritis in the literature. The present study compares 30 early onsets OA patients divided equally into 3 groups who had experienced no pain reduction following conservative and minimally invasive arthrocentesis and arthroscopy treatment. All patients had retrodiscitis and synovitis on arthroscopic examination and were without systemic joint disease, septic, or autoimmune arthritis. Only patients with unilateral TMJ symptoms were included in this study. Pain intensity was recorded for each patient using a 0-10 VAS scale. Maximum Interincisal Opening (MIO) was also recorded. This assessment was performed at the pretreatment and then at an examination 3 months after administration of 2 intra-articular applications of autologous PRP (Group A), 2 intra-articular injections of Hyaluronic Acid (HA) (Group B), or commencement of conservative therapy only with soft diet and analgetics (Group C). The results after 3 months revealed that intra-articular injection of autologous PRP appeared to be an effective treatment method for patients with early OA in this study. At the 3-month follow-up, patients from group A improved their mouth opening significantly. Majority of the PRP patients (Group A) showed decreased pain. The average pain score before PRP administration was 7, while 3 months after PRP administration the pain score was 3.5. In conclusion, the use of PRP is an effective treatment option for early TMJ OA.


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