Platelet-Rich Plasma (PRP) in a Post Radiotherapy Sternal Ulcer in a Patient with Hodgkin's Lymphoma
- *Corresponding Author:
- Pasquale Fino
Department of Plastic
Reconstructive and Aesthetic Surgery
University of Rome “ La Sapienza”
Policlinico Umberto I, Viale Pantelleria, 35
Scala B, Interno 1/A, 00141, Rome, Italy
Fax: +39-06/491525/+39-06 64491523
E-mail: [email protected],
Received date: August 21 2014 Accepted date: August 18, 2015 Published date: August 21, 2015
Citation: Fioramonti P, Fino P, Ferrazza G, Capria V, Onesti MG (2015) Platelet-Rich Plasma (PRP) in a Post Radiotherapy Sternal Ulcer in a Patient with Hodgkin's Lymphoma. J Blood Disord Transfus 6: 299. doi:10.4172/2155-9864.1000299
Copyright: © 2015 Fioramonti P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Radiotherapy is an essential part of the multidlevel treatment for Hodgkin’s Lymphoma. However but it is responsible for several adverse effects on different tissues. The tissue damage may occur immediately or over a prolonged period of time. A 33 years old woman, with a diagnosis of Hodgkin lymphoma, nodular sclerosis histotype, II grade according to WHO classification, stage 2A has been examined for this study. At the physical examination, the ulcer was of 6 x 5 cm, 2 cm deep, of circular shape, with uneven margins. There was rash around the lesion too. The wound was infected with abundant serous and fibrinous exudate in the center and squamous-crostous formations around the center itself. The lesion was bleeding and smelled bad. Platelet gel has been applied once a week with a control after 3 days to check and evaluate the conditions of the medication.
The situation improved after the first two applications with a noticeable reduction of the rash and inflammation. During the fourth level of application the first areas of granulation tissue appeared and by the end of the eighth cycle, the therapy concluded with the lesion completely re-epitelized. Platelet gel showed to be effective and accomplished a complete re-epitelization of the lesion after eight cycles. At the same time, it allowed us to proceed with the myeloablative chemotherapy, which was the most appropriate therapeutic choice for the Hodgkin’s disease but was supposed to enhance the risk of infective complications of the ulcer.