Pleiotropy of Presenilins
Airong Li* and Rudolph E Tanzi
Genetics and Aging Research Unit, Department of Neurology, Mass General Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, MA, USA
- *Corresponding Author:
- Airong Li
Genetics and Aging Research Unit
Massachusetts General Hospital, Harvard Medical School
CNY114, 16th Street Charlestown, MA 02129, USA
Received Date: October 18, 2012; Accepted Date: October 18, 2012; Published Date: October 20, 2012
Citation: Li A, Tanzi RE (2012) Pleiotropy of Presenilins. Hereditary Genet 2: e105. doi: 10.4172/2161-1041.1000e105
Copyright: © 2012 Li A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pleiotropy genes affect multiple and apparently unrelated phenotypes. Here we describe pleiotropy gene
presenilins, mutations in which have been detected in three genetically heterogeneous diseases: early-onset familial Alzheimer’s disease, familial or sporadic dilated cardiomyopathy, and familial hidradenitis suppurativa.