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Low Antigen-specific T-cell Response in Pulmonary Tuberculosis is Associated with Impaired Phenotype and Functions of Interferon-and#945; Induced Dendritic Cells | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Low Antigen-specific T-cell Response in Pulmonary Tuberculosis is Associated with Impaired Phenotype and Functions of Interferon-α Induced Dendritic Cells

Sakhno LV1*, Leplina OYu1, Tikhonova MA1, Shevela EYa1, Nikonov SD2, Zhdanov OA2, Ostanin AA1 and Chernykh ER1
1Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia
2Novosibirsk Tuberculosis Clinical Hospital №1, Russia
Corresponding Author : Dr. Ludmila Sakhno
Research Institute of Clinical Immunology
Laboratory of Cellular Immunotherapy
Yadrintsevskaya St., 14, Novosibirsk 630099, Russia
Tel: +7-383-236-03-29
E-mail: [email protected]
Received: September 06, 2013; Accepted: October 28, 2013; Published: October 31, 2013
Citation: Sakhno LV, Leplina OYu, Tikhonova MA, Shevela EYa, Nikonov SD, et al. (2013) Low Antigen-specific T-cell Response in Pulmonary Tuberculosis is Associated with Impaired Phenotype and Functions of Interferon-a Induced Dendritic Cells. J Clin Cell Immunol 4:169. doi:10.4172/2155-9899.1000169
Copyright: © 2013 Sakhno LV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The phenotype and functions of monocyte-derived dendritic cells (DCs), generated upon stimulation with GMCSF and IFN-α, were investigated in pulmonary tuberculosis (TB). Patient INF-DC cultures were characterized by increased number of CD14+ cells, lowered level of CD25+ cells and increased expression of B7-H1. Besides, DCs produced enhanced levels of IL-6 and IL-10 and differed by reduced secretion of INF-γ and INF-α. Patient IFN-DCs had lower capacity to stimulate allogeneic T-cell proliferation and induce CD3+IFN-γ+ T cells but increased ability to activate CD3+IL-4+ T cells in mixed lymphocyte culture. The most pronounced increase of IL-10 production, as well as the decrease of allostimulatory activity and the alteration of T1/T2 stimulatory activity of DCs were registered in patients with low PPD-induced proliferative response. The data obtained evidence the tolerogenic phenotype of monocyte-derived IFN-DCs and the association of DC impairment with decreased antigen-specific T cell response in TB patients.


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