alexa Plurihormonality and Pluripotentiality of GH-Secreting Adenoma Based on Pathological Analysis of 242 patients with Acromegaly
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Plurihormonality and Pluripotentiality of GH-Secreting Adenoma Based on Pathological Analysis of 242 patients with Acromegaly

Hidetoshi Ikeda*
Research Institute for Pituitary Diseases, Southern Tohoku General Hospital, Koriyama, Fukushima 963-8563, Japan
Corresponding Author : Hidetoshi Ikeda
Research Institute for Pituitary Diseases
Southern Tohoku General Hospital
Koriyama, Fukushima 963-8563, Japan
Tel: +81-24-934-5322
Fax: +81-24-922-5320
E-mail: [email protected]
Received September 21, 2012; Accepted October 27, 2012; Published October 29, 2012
Citation: Ikeda H (2012) Plurihormonality and Pluripotentiality of GH-Secreting Adenoma Based on Pathological Analysis of 242 patients with Acromegaly. J Metabolic Synd S2:003. doi:10.4172/2167-0943.S2-003
Copyright: © 2012 Ikeda H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Aim: To disclose the nature of plurihormonality and pluripotentiality of growth hormone (GH)-secreting adenomas.
Methods: A total of 242 patients with GH-secreting adenomas were studied by immunohistochemistry, electron microscopy and clonal analysis (X-linked human androgen receptor gene assay).
Results:
GH-secreting adenoma showed a greater variety and number of hormones produced compared with those of PRL-secreting adenomas (p<0.01, Welch’s t-test). The number of cases with GH-secreting adenoma that simultaneously produced ACTH were 50 (21%) out of 242. There were two different types of co-localization of ACTH- and GH-secreting cells within adenoma; (1) adenoma with co-localized ACTH- and GH-immunoreactive cells in a random pattern, and (2) adenoma with a small cell cluster of ACTH-immunoreactive cells within GH-secreting adenomas. There were three different tissue phenotypes in GH-secreting adenomas; (a) mixed tumors composed of adenoma and neuronal cells, (b) co-localization of GHsecreting adenoma and mature bone tissue, and (c) co-localization of GH-secreting adenoma and nerve bundles. In this study, immunoreactivity for nestin was observed in these three different phenotypes of GH-secreting adenomas, not only in perivascular spaces of pituitary tumor vessels but also in parenchymal cells of the pituitary adenoma.
Conclusion: Various kinds of cells can differentiate from the stem cells in GH-secreting adenomas, which may result in plurihormonality and pluripotentiality of adenomas.

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