alexa Poly D, L-lactide-co-glycolic Acid (PLGA)-encapsulated CpG-oligonucleotide (ODN) on Immune Response in Cyprinus carpio against Aeromonas hydrophila
ISSN: 2155-9546

Journal of Aquaculture Research & Development
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Research Article

Poly D, L-lactide-co-glycolic Acid (PLGA)-encapsulated CpG-oligonucleotide (ODN) on Immune Response in Cyprinus carpio against Aeromonas hydrophila

Govintharaj Yogeshwari1, Chandrasekar Jagruthi1, Jesu Arockiaraj2 and Ramasamy Harikrishnan3*

1Department of Biotechnology, Bharath College of Science and Management, Thanjavur-613 005, Tamil Nadu, India

2Division of Fisheries Biotechnology and Molecular Biology, Department of Biotechnology, Faculty of Science and Humanities, SRM University, Kattankulathur-603 203,Chennai, Tamil Nadu, India

3Department of Zoology, Pachaiyappa’s College for Men, Kanchipuram-631 501, Tamil Nadu, India

*Corresponding Author:
HariKrishna R
Department of Zoology
Pachaiyappa’s College for Men
Kanchipuram - 631 501
Tamil Nadu, India
Tel: +91 4362 227937
E-mail: [email protected]

Received Date: January 14, 2015; Accepted Date: February 14, 2015; Published Date: March 15, 2015

Citation: Yogeshwari G, Jagruthi C, Arockiaraj J, Harikrishnan R (2015) Poly D, L-lactide-co-glycolic Acid (PLGA)-encapsulated CpG-oligonucleotide (ODN) on Immune Response in Cyprinus carpio against Aeromonas hydrophila. J Aquac Res Development 6:327. doi:10.4172/2155-9546.1000327

Copyright: © 2015 Yogeshwari G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The effect of Poly D, L-lactide-co-glycolic acid (PLGA) encapsulated ODN 1668 nanospheres (NS) on innate and adaptive immune response in common carp, Cyprinus carpio against Aeromonas hydrophila is reported. PLGAencapsulated ODN biodegradable NS did not have a significant impact on particle size as expected of the particles was clearly positive for non-coated and coated PLGA/ODN NS. The myeloperoxidase (MPO) activity and serum haemolysin titre significantly increased in fish injected with ODN 1668 and PLGA-encapsulated ODN 1668 groups on week 4 whereas the respiratory burst (RB) activity significantly increased when administered with ODN 1668 and PLGA-encapsulated ODN 1668 (PLGA-ODN 1668) from weeks 1 to 4. The haemoagglutinating titre was significantly enhanced in PLGA-encapsulated ODN 1668 group on week 2 while in ODN 1668 and PLGA-encapsulated ODN 1668 groups the increase manifested on week 4. The bacterial agglutination titre significantly increased in ODN 1668 and PLGA-encapsulated ODN 1668 groups on weeks 2 and 4. The cumulative mortality in ODN 1668 and PLGAencapsulated ODN 1668 groups were 10% each whereas it was 15% in PLGA group. This study indicates that single administration of PLGA-encapsulated ODN 1668 nanospheres elicits better immune response than PLGA or ODN 1668 alone in C. carpio against A. hydrophila.

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