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ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Polyglutamine Diseases-Understanding the Mechanism of Pathogenesis

Sonali Sengupta1* and Saurabh Bhattacharya2
1Division of Biomolecules and Genetics, School of Biosciences and Technology (SBST), VIT University, India
2Cytogenetics Department, Dr. Lal Path Labs Pvt. Ltd, National Research Laboratory, New Delhi, India
*Corresponding Author : Sonali Sengupta
Division of Biomolecules and Genetics
School of Biosciences and Technology (SBST)
VIT University, Tamil Nadu, India
Tel: +919566812955
E-mail: [email protected]
Received: January 05, 2016 Accepted: February 18, 2016 Published: February 22, 2016
Citation: Sengupta S, Bhattacharya S (2016) Polyglutamine Diseases-Understanding the Mechanism of Pathogenesis. J Neurol Disord 4:252. doi:10.4172/2329-6895.1000252
Copyright: © 2016 Sengupta S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Protein misfolding has been implicated in a large number of diseases, which are now grouped under the name of Protein conformational disorders (PCDs). Few examples of diseases that fall in this group are Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. All these disorders are characterized by sets of protein that misfold and aggregate in specific tissues. In order to identify and develop possible routes of therapeutic strategies, scientists have discovered several modifiers for these fatal diseases. These modifiers, primarily identified using models systems, include heat shock proteins, components of UPS pathway and autophagy, transcription factors, detoxifying enzymes, several RNA binding proteins, and RNA species, among other examples. These reviews will focus primarily on cellular processes that are affected in Polyglutamine disorders.

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