alexa Polymegathism, Pleomorphism, and Endothelial Cell Count after Selective Laser Trabeculoplasty
ISSN: 0974-8369

Biology and Medicine
Open Access

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Research Article

Polymegathism, Pleomorphism, and Endothelial Cell Count after Selective Laser Trabeculoplasty

N Kurysheva* and E Shatalova

Ophthalmological Center of the Federal Medical and Biological Agency, Clinical Hospital No. 86, 15 Gamalei St., Moscow 123098, Russia

*Corresponding Author:
Kurysheva N
Diagnostic Department
Ophthalmological Center of the Federal Medical and Biological Agency
Clinical Hospital No. 86, 15 Gamalei St.
Moscow 123098, Russia
E-mail: [email protected]

Received Date: June 22, 2016; Accepted Date: August 25, 2016; Published Date: October 07, 2016

Citation: Kurysheva N, Shatalova E (2016) Polymegathism, Pleomorphism and Endothelial Cell Count after Selective Laser Trabeculoplasty. Biol Med (Aligarh) 8: 343. doi:10.4172/0974-8369.1000343.

Copyright: © 2016 Kurysheva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The purpose of the study was to investigate the changes in the endothelial cell count and cell’s polymegathism and pleomorphism after selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG). SLT has been performed on 18 patients (22 eyes). Each patient underwent confocal microscopy 1 h prior to the laser surgery and then 1 h, 1 day, 1 week, and 1 month after SLT. The obtained micrographs were then analyzed in order to study the infl uence of SLT on the corneal endothelium. The difference in the mean corneal endothelial cell density, polymegathism, and pleomorphism at different time intervals was found to be statistically signifi cant. The mean endothelial cell count was reduced in 1 week after SLT from 2442 6 326 per mm2 to 2352 6 460 per mm2; polymegathism was increased from 46.1 6 11.7% to 50.9 6 13.4%; and pleomorphism was decreased from 46.2 6 11.2% to 40.9 6 7.2%. Cellular damage was also observed on the micrographs that were made in the follow-up after SLT. The highest quantity of damaged cells was observed 1 h after SLT. After 1 month, endothelial integrity was completely restored. If damaging does occur after SLT, it is not severe enough to induce serious changes in the endothelial monolayer. Nevertheless, extra care should be taken when choosing an approach to treating patients with low endothelial cell density.


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