alexa Polymer Based Nano-Formulation of Diindolylmethane with
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Polymer Based Nano-Formulation of Diindolylmethane with High Oral Bioavailability

Vsevolod Kiselev1, Eugenii Klinskiy2, Shengmin Lee2, Ekaterina Muyzhnek3, Alexander Semov2 and Valery Alakhov2*

1National Research Centre “Kurchatov Institute”, Moscow, Russia

2Supratek Pharma Inc. Montreal, Quebec, Canada

3MiraxBioPharma, Moscow, Russia

*Corresponding Author:
Valery Alakhov
Supratek Pharma Inc.
Montreal, Quebec, Canada
Tel: 1-514-422-9191
Fax: 1-514-422-9410
E-mail: [email protected]

Received Date: December 10, 2012; Accepted Date: February 06, 2013; Published Date: February 08, 2013

Citation: Kiselev V, Klinskiy E, Lee S, Muyzhnek E, Semov A, et al. (2013) Polymer Based Nano-Formulation of Diindolylmethane with High Oral Bioavailability. J Nanomed Nanotechol 4:162. doi:10.4172/2157-7439.1000162

Copyright: © 2013 Kiselev V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

At the present, a high potential of 3,3’-diindolylmethane (DIM) as a new preventive and therapeutic agent in oncology is well established, due to its ability to target multiple components of cancer cell cycle regulation, survival and progression. However, a very low bioavailability of DIM remains the major challenge for its efficient development as novel medicine. In this work, we have developed a polymer based nano-formulation comprising a non-ionic block copolymer, Pluronic F127 that increases oral bioavailability of DIM by almost one order of magnitude, as compared to the presently marketed products such as crystalline DIM and BioResponse DIM. The pharmacokinetic parameters established in the present study revealed that AUC and Cmax of the new formulation dosed at 60 mg/kg were 7.06 ± 0.93 μg ∙ h/mL, and 3.08 ± 0.17 μg/mL, while in the case of crystalline DIM dosed at the same dose AUC and Cmax were 0.97 ± 0.08 μg ∙ h/mL, and 0.18 ± 0.02 μg/mL. BioResponce DIM showed AUC and Cmax of 1.05 ± 0.05 μg ∙ h/mL, and 0.22 ± 0.02 μg/mL, respectively.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords