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ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Review Article

Polymer Nanoparticles: Newer Strategies towards Targeted Cancer Therapy

Kamlesh Shroff and Ajay Vidyasagar*
Department of Chemical Engineering & Materials Science, University of Minnesota.421 Washington ave SE, Minneapolis, MN – 55455, USA
Corresponding Author : Ajay Vidyasagar
Department of Chemical Engineering & Materials Science
University of Minnesota, 421 Washington ave SE
Minneapolis, MN – 55455, USA
E-mail: [email protected]
Received July 01, 2013; Accepted August 26, 2013; Published August 28, 2013
Citation: Shroff K, Vidyasagar A (2013) Polymer Nanoparticles: Newer Strategies towards Targeted Cancer Therapy. J Phys Chem Biophys 3:125. doi:10.4172/2161-0398.1000125
Copyright: © 2013 Shroff K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Encapsulation of therapeutic drugs inside nanoparticles has become the new norm in the field of drug delivery. Nanoparticles increase the therapeutic efficacy of the drugs by providing high loading efficiencies, shielding when in circulation, ability to target tumors, enhanced accumulations, and triggered release inside tumors. Polymeric nanoparticles have seen an unprecedented growth and usage in drug delivery and diagnostics in recent decades, and have emerged as extremely promising candidates for targeted delivery owing to their tunable properties, and the flexibility to design systems which respond to external stimuli such as pH, hyperthermia, redox, ultrasound, and magnetic field. This review summarizes recent exciting developments in the field of targeted polymeric nanoparticles for delivery of anti-cancer drugs, with a particular focus on functionalization with ligands, stimuli responsive and biodegradable systems. Further a critical overview of their design principles, drug release performance, and therapeutic advantages over conventional nanoparticles is discussed.

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