alexa Polymer-Coated Hydroxyapatite Nanoparticles for the Del
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins

Thomas L Moore1, Ann-Sofie Schreurs2, Rachel A Morrison1, Erika K Jelen1, Joachim Loo3, Ruth K Globus2* and Frank Alexis1,4*

1Department of Bioengineering, Clemson University, Clemson, SC 29634, USA

2Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA

3School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore

4Institute of Biological Interfaces of Engineering, Department of Bioengineering, Clemson University, Clemson, SC 29634, USA

*Corresponding Author:
Frank Alexis
Department of Bioengineering
Clemson University, Clemson
SC 29634, USA
Tel: 864-656-3051
Fax: 864-656-4466
E-mail: [email protected]

Ruth Globus
Space Biosciences Division
NASA Ames Research Center
Moffett Field, CA 94035, USA
Tel: 864-656-3051
Fax: 864-656-4466
E-mail: [email protected]

Received Date: September 01, 2014; Accepted Date: October 15, 2014; Published Date: October 24, 2014

Citation: Moore TL, Schreurs AS, Morrison RA, Jelen EK, Loo J, et al. (2014) Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins. J Nanomed Nanotechnol 5:237. doi:10.4172/2157-7439.1000237

Copyright: © 2014 Moore TL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Statin drugs have been previously reported to increase the activity of osteoblasts, and are being investigated to treat low bone density pathologies. A controlled release nanoparticle drug delivery system may be used to prolong the exposure of osteoblasts to statin. Furthermore, nano-hydroxyapatite (nHA) has known osteoconductive and osteoinductive properties. The success of nanoparticle drug delivery systems is associated with safety, stability, biodegradability, and pharmacological parameters. nHA have been used as gene and drug delivery vehicles, however in vivo studies have shown that nHA aggregate, accumulate in the lungs, and impede the function of pulmonary surfactant. To address some of these challenges, we present a nHA coated with the biodegradable co-polymer poly(glycolide)- poly(ethylene glycol) (PGA-PEG). PGA coating thickness could be precisely tuned by surface initiated ring opening polymerization to control the release of lovastatin. PGA-PEG coated nHA were shown to be internalized in human osteoblasts, and were also shown to maintain 70% cell viability in human umbilical vein endothelial cells at doses up to 500 μg mL-1 in vitro. Preliminary in vivo maximum tolerated dose studies showed that PGA-PEG coated nHA were less toxic compared to uncoated nHA. This hybrid polymer-HA nanoparticle drug delivery system has potential as a controlled release system for the delivery of statins to treat low bone density pathologies.

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