alexa Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins | OMICS International | Abstract
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins

Thomas L Moore1, Ann-Sofie Schreurs2, Rachel A Morrison1, Erika K Jelen1, Joachim Loo3, Ruth K Globus2* and Frank Alexis1,4*

1Department of Bioengineering, Clemson University, Clemson, SC 29634, USA

2Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA

3School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore

4Institute of Biological Interfaces of Engineering, Department of Bioengineering, Clemson University, Clemson, SC 29634, USA

*Corresponding Author:
Frank Alexis
Department of Bioengineering
Clemson University, Clemson
SC 29634, USA
Tel: 864-656-3051
Fax: 864-656-4466
E-mail: [email protected]

Ruth Globus
Space Biosciences Division
NASA Ames Research Center
Moffett Field, CA 94035, USA
Tel: 864-656-3051
Fax: 864-656-4466
E-mail: [email protected]

Received Date: September 01, 2014; Accepted Date: October 15, 2014; Published Date: October 24, 2014

Citation: Moore TL, Schreurs AS, Morrison RA, Jelen EK, Loo J, et al. (2014) Polymer-Coated Hydroxyapatite Nanoparticles for the Delivery of Statins. J Nanomed Nanotechnol 5:237. doi:10.4172/2157-7439.1000237

Copyright: © 2014 Moore TL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Statin drugs have been previously reported to increase the activity of osteoblasts, and are being investigated to treat low bone density pathologies. A controlled release nanoparticle drug delivery system may be used to prolong the exposure of osteoblasts to statin. Furthermore, nano-hydroxyapatite (nHA) has known osteoconductive and osteoinductive properties. The success of nanoparticle drug delivery systems is associated with safety, stability, biodegradability, and pharmacological parameters. nHA have been used as gene and drug delivery vehicles, however in vivo studies have shown that nHA aggregate, accumulate in the lungs, and impede the function of pulmonary surfactant. To address some of these challenges, we present a nHA coated with the biodegradable co-polymer poly(glycolide)- poly(ethylene glycol) (PGA-PEG). PGA coating thickness could be precisely tuned by surface initiated ring opening polymerization to control the release of lovastatin. PGA-PEG coated nHA were shown to be internalized in human osteoblasts, and were also shown to maintain 70% cell viability in human umbilical vein endothelial cells at doses up to 500 μg mL-1 in vitro. Preliminary in vivo maximum tolerated dose studies showed that PGA-PEG coated nHA were less toxic compared to uncoated nHA. This hybrid polymer-HA nanoparticle drug delivery system has potential as a controlled release system for the delivery of statins to treat low bone density pathologies.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7