alexa Polymorphisms rs1800587 and rs1143634 of the Interleuki
ISSN: 2475-3211

Journal of Diabetic Complications & Medicine
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Research Article

Polymorphisms rs1800587 and rs1143634 of the Interleukin-1α Gene are associated with the Progression of Carotid Atherosclerosis in Caucasians with Type 2 Diabetes Mellitus

Aleš Pleskovič1, Jovana Nikolajević Starcević2, Sara Mankoč2, Ines Cilenšek2, Marija Šantl Letonja3, Jana Makuc4, Andreja Cokan Vujkovac4 and Daniel Petrovič2,5,*

1Department of Cardiology, University Medical Centre, Ljubljana, Slovenia

2Institute of Histology and Embryology, University of Ljubljana, Slovenia

3General Hospital Rakičan, Murska Sobota, Slovenia

4General Hospital Slovenj Gradec, Slovenia

5MC Medicor International Center for Cardiovascular Diseases, Izola-Ljubljana, Slovenia

*Corresponding Author:
Daniel Petrovič
Faculty of Medicine, Institute of Histology and Embryology
University Ljubljana, Slovenia
Tel: +386 1 543 7367
Fax+ 386 1543 7361
E-mail: [email protected]

Received date: August 05, 2016; Accepted date: September 02, 2016; Published date: September 08, 2016

Citation: Pleskovic A, Starcevic JN, Mankoc S, Cilenšek I, Letonja MS, et al. (2016) Polymorphisms rs1800587 and rs1143634 of the Interleukin-1a Gene are associated with the Progression of Carotid Atherosclerosis in Caucasians with Type 2 Diabetes Mellitus. J Diabetic Complications Med 1:113.

Copyright: © 2016 Pleskovic A et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Our study was designed to test the possible association between either polymorphisms T889C (rs1800587) or C3954T (rs1143634) of the interleukin-1 alpha (IL-1α) gene with subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Moreover, the effect of both polymorphisms on progression of carotid atherosclerosis in 3.8-year follow-up was studied. Patients and methods: 595 subjects with T2DM were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed with ultrasound at the time of recruitment and after 3.8-years. Genotyping of two polymorphisms (rs1800587, rs1143634) was performed with real-time PCR System. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of IL-1α rs1800587 and rs1143634 polymorphisms upon enrolment. Multiple linear regression analysis revealed the association of IL-1α rs1143634 on total plaque thickness progression in a 3.8 year follow up. Conclusions: An association between either the IL-1α rs1800587 or rs1143634 and total plaque thickness at the time of recruitment was reported. Additionally, we demonstrated the effect of the IL-1α rs1143634 on total plaque thickness progression in the 3.8-year follow-up in patients with T2DM.


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