alexa Poly(N-Isopropylacrylamide-Co-Acrylic Acid) Smart Nanocarriers for Drug Release: A Study of Theophylline Delivery
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Poly(N-Isopropylacrylamide-Co-Acrylic Acid) Smart Nanocarriers for Drug Release: A Study of Theophylline Delivery

Álvarez–Bautista A1,2,3*, Mendizábal E4, Duarte CMM2,3 and Katime I1

1New Materials and Supramolecular Spectroscopy Group. Department of Physical Chemistry, University of the Basque Country (UPV/EHU), Spain

2Instituto de Tecnologia Química e Biológica (ITQB), Universidade Nova de Lisboa, Avenida da Republica, 2780-157 Oeiras, Portugal

3Instituto de Biologia Experimental e Tecnológica (IBET), Avenida da República, Quinta-do-Marquês, Estação Agronómica Nacional, Apartado 12, 2781-901 Oeiras, Portugal

4CUCEI, Universidad de Guadalajara (Jalisco), México

Corresponding Author:
A. Álvarez–Bautista
Instituto de Biología Experimental e Tecnologica (IBET)
Avenida da República, Quinta-do-Marquês
Estação Agronómica Nacional, Apartado 12
2781-901 Oeiras, Portugal
Tel: 351 21 442 7787
E-mail: [email protected]

Received date: September 30, 2015 Accepted date: December 19, 2015 Published date: December 21, 2015

Citation:Álvarez–Bautista A, Mendizábal E, Duarte CMM, Katime I (2015) Poly(N–Isopropylacrylamide–Co–Acrylic Acid) Smart Nanocarriers for Drug Release: A Study of Theophylline Delivery. J Mol Genet Med 9:196. doi:10.4172/1747-0862.1000196

Copyright: ©2015 Álvarez–Bautista A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Copolymeric nanoparticles of poly(N–isopropylacrylamide–co–acrylic acid) have been synthesized by inverse microemulsion polymerization. The obtained nanoparticles have been characterized by FTIR and DSC, to detect her molecular structure and glass transition temperatures respectively, by transmission electron microscopy (TEM) and quasielastic light scattering (QLS) to determine the sizes and size distribution of gels synthesized. The swelling of these nanogels has been studied in order to know their response at different pH and crosslinking agent concentration. These nanoparticles have subsequently been charged with a vasodilator drug (theophylline) to study the release–kinetics of the drug release at different pH. These nanogels have shown a controlled release at basic environment. After further biological viability studies this system could be used as smart carriers in nanomedicine.


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