alexa Positron Emission Tomography-Computed Tomography Scan Captures the Effects of Cellular Therapy in a Case of Cerebral Palsy
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Positron Emission Tomography-Computed Tomography Scan Captures the Effects of Cellular Therapy in a Case of Cerebral Palsy

Alok Sharma, Pooja Kulkarni*, Hemangi Sane, Nandini Gokulchandran, Prerna Badhe, Mamta Lohia and Priti Mishra
Department of Medical Services and Clinical research, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur, Mumbai-400071, India
Corresponding Author : Ms. Pooja Kulkarni (Clinical research associate)
NeuroGen Brain and Spine Institute
Surana Sethia Hospital and Research Centre
Suman nagar, Sion-Trombay Road
Chembur, Mumbai-400071, India
E-mail: [email protected]
Received August 13, 2012; Accepted August 25, 2012; Published August 27, 2012
Citation: Sharma A, Kulkarni P, Sane H, Gokulchandran N, Badhe P, et al.(2012) Positron Emission Tomography-Computed Tomography Scan Captures the Effects of Cellular Therapy in a Case of Cerebral Palsy. J Clin Case Rep 2:195. doi:10.4172/2165-7920.1000195
Copyright: © 2012 Sharma A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cerebral palsy is defined as motor impairment that limits activity, and is caused by non-progressive disruption during cerebral development in fetus or infant. The standard treatment is focused on rehabilitation and symptomatic management, which does not address the underlying brain damage. Recently cellular therapy has been seen as promising strategy to improve function of damaged areas of brain. Many mechanisms of action are postulated including cytokine release, angiogenesis, activation of satellite cells, decrease inflammation decrease neuronal apoptosis; and neuronal regeneration. We present a case of a two year old girl with spastic cerebral palsy, who was administered autologous bone marrow derived mononuclear cells intrathecally. Six months after the therapy she showed significant functional improvements along with correlating dramatic changes in Positron Emission Tomography-Computed Tomography scan. These changes provide objective evidence of functional restoration of affected areas of brain by cellular therapy.

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