alexa Possible Anti-oxidant Effect of Lamotrigine in Nucleus Accumbens of Mice Exposed to Picrotoxin
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Possible Anti-oxidant Effect of Lamotrigine in Nucleus Accumbens of Mice Exposed to Picrotoxin

Sahar Mohamed Kamal*
Associate Professor, Department of Pharmacology, University of Ain-Shams, Egypt
Corresponding Author : Dr. Sahar Mohamed Kamal
Faculty of Medicine, Associate Professor
Department of Pharmacology
University of Ain Shams, Cairo – Egypt
Tel: 00202-24186992
E-mail: [email protected]
Received February 11, 2013; Accepted March 21, 2013; Published March 24, 2013
Citation: Kamal SM (2013) Possible Anti-oxidant Effect of Lamotrigine in Nucleus Accumbens of Mice Exposed to Picrotoxin. J Neurol Disord 1:108. doi: 10.4172/2329-6895.1000108
Copyright: © 2013 Kamal SM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The present study was performed to investigate whether or not lamotrigine (an anti-epileptic drug by sodiumchannel blockade and also increases gamma-aminobutyric acid [GABA]) could increase some anti-oxidant markers in the nucleus accumbens of mice exposed to picrotoxin as a model simulating convulsions in human. The results indicated that the anti-epileptic drug significantly increased the activities of glutathione peroxidase and catalase enzymes in nucleus accumbens homogenates as well as the contents of superoxide dismutase enzyme in red blood cells (RBCs) lysates in this model of convulsion. In addition the tested drug significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in nucleus accumbens homogenates. So, the present study showed that the tested antiepileptic drug could potentiate its anticonvulsant activity via a possible anti-oxidant activity.

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