alexa Possible Contribution of Microglial Glutamate Receptors to Inflammatory Response upon Neurodegenerative Diseases | OMICS International
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Possible Contribution of Microglial Glutamate Receptors to Inflammatory Response upon Neurodegenerative Diseases

Mami Noda1* and Kaoru Beppu2,3
1Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2Division of Cerebral Structure, National Institute for Physiological Sciences, Japan
3Department of Physiological Sciences, Graduate University for Advanced Studies, Okazaki, Japan
Corresponding Author : Mami Noda
Laboratory of Pathophysiology
Graduate School of Pharmaceutical Sciences
Kyushu University, Fukuoka 812-8582, Japan
Tel/Fax: 81-92-642-6574
E-mail: [email protected]
Received July 31, 2013; Accepted September 06, 2013; Published September 09, 2013
Citation: Noda M, Beppu K (2013) Possible Contribution of Microglial Glutamate Receptors to Inflammatory Response upon Neurodegenerative Diseases. J Neurol Disord 1:131. doi: 10.4172/2329-6895.1000131
Copyright: © 2013 Noda M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Abstract

Microglial cells actively contribute to tripartite synapses by direct contact or releasing diffusible factors. In neuronmicroglia interaction, there are number of candidates as microglial signalling to neurons, for example neurotrophic factors, pro-inflammatory cytokines and chemokines. However, little is known about neuronal signalling to microglia. Microglial cells express various kinds of neurotransmitter receptors including glutamate receptors; both ionotropic and metabotropic glutamate receptors. Among them, microglial AMPA receptors are impermeable to Ca2+ due to the expression of GluA2. GluA2 is an important subunit in determining the functional properties of AMPA receptors, such as Ca2+ -permeability, conductance, assembly and trafficking. Activation of microglia induces membrane translocation of GluA2, while internalization of other subunits occurs, and nearly homomeric GluA2 subunits are suggested as the main reason for low conductance of AMPA receptors in activated microglia. Since low expression of GluA2 was reported in some neurodegenerative diseases, lack of GluA2 in microglia as well as in neurons contribute to excitotoxicity by excess release of proinflammatory cytokines such as TNF-α. Therefore, involvement of microglia in glutamatergic synaptic transmission may be also important to understand the mechanism of some neurodegeneration in which low GluA2 is suggested.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version