alexa Possible Dual Immunoreactivity for Laminin-332 and Type VII Collagen in a Case with Vancomycin-Induced Linear Iga Bullous Dermatosis Manifesting as Erythroderma | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

Possible Dual Immunoreactivity for Laminin-332 and Type VII Collagen in a Case with Vancomycin-Induced Linear Iga Bullous Dermatosis Manifesting as Erythroderma

Yuko Asoh1, Noritaka Oyama2*, Taeko Nakamura-Wakatsuki3, Toshiyuki Yamamoto3 and Minoru Yoneda4

1Division of Dermatology, Saitama Medical Center, Saitama, Japan

2Southern Tohoku General Hospital, Saitama, Japan

3Fukushima Medical University School of Medicine, Saitama, Japan

4Division of Internal Medicine, Kashima Kosei General Hospital, Fukushima, Japan

*Corresponding Author:
Dr. Noritaka Oyama
Department of Dermatology
Southern Tohoku General Hospital, Koriyama, Japan
Tel:
+81249345322
Fax: +81249343165
E-mail: [email protected]

Received date: July 11, 2012; Accepted date: August 09, 2012; Published date:August 14, 2012

Citation: Asoh Y, Oyama N, Nakamura-Wakatsuki T, Yamamoto T, Yoneda M (2012) Possible Dual Immunoreactivity for Laminin-332 and Type VII Collagen in a Case with Vancomycin-Induced Linear Iga Bullous Dermatosis Manifesting as Erythroderma. J Clin Exp Dermatol Res 3:151. doi: 10.4172/2155-9554.1000151

Copyright: ©2012 Asoh Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We report a unique case of vancomycin-induced linear IgA bullous dermatosis (LABD) presenting as erythroderma. Direct immunofluorescence showed a linear IgA deposition at the dermal side of the basement membrane zone (BMZ), and double immunostaining using patients’ skin as a substrate revealed that the in vivo IgA signal co-localized with laminin-332 and type VII collagen. Our case is the first documentation of vancomycin-induced LABD, in which the pathogenic IgA deposit would concomitantly recognize the two distinct antigens at the dermal BMZ.

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