Letter to Editor
Possible Role for Hepcidin in Acute Neuroleptic Malignant Syndrome
Mental Health Service, VA Boston Healthcare System, Harvard Medical School Department of Psychiatry, Boston, MA, USA
- Corresponding Author:
- Ronald Gurrera
Mental Health Service
VA Boston Healthcare System
Harvard Medical School Department of Psychiatry
Boston, MA, USA
E-mail: [email protected]
Received Date: May 02, 2016; Accepted Date: May 21, 2016; Published Date: May 24, 2016
Citation: MGurrera R (2016) Possible Role for Hepcidin in Acute Neuroleptic Malignant Syndrome. Brain Disord Ther 5:216. doi:10.4172/2168-975X.1000216
Copyright: © 2016 Gurrera R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Acute reductions in serum iron levels are frequently associated with neuroleptic malignant syndrome (NMS) and have been implicated in the progression of catatonia to NMS. Iron catalyzes dopamine synthesis through its role as a cofactor for tyrosine hydroxylase, and modulates expression of the dopamine (D2) receptor and dopamine transporter proteins.