Post Chemoradiation PET SUV is highly Predictive of Overall Survival in Esophageal CancerH Lomas1, SE Hoffe2, J Weber3, TJ Dilling2, MD Chuong2, K Almhanna3, RC Karl3, K. Meredith3 and R Shridhar2*
- *Corresponding Author:
- Ravi Shridhar, MD, PhD
Department of Radiation Oncology
H. Lee Moffitt Cancer Center & Research Institute
12902 Magnolia Drive, Tampa, Florida, USA
E-mail: [email protected]
Received date: March 17, 2012; Accepted date: March 26, 2012; Published date: March 30, 2012
Citation: Lomas H, Hoffe SE, Weber J, Dilling TJ, Chuong MD, et al. (2012) Post Chemoradiation PET SUV is highly Predictive of Overall Survival in Esophageal Cancer. J Nucl Med Radiat Ther 3:125. doi:10.4172/2155-9619.1000125
Copyright: © 2012 Lomas H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: Positron Emission Tomography (PET) scan is a vital tool in the staging, prognosis and response evaluation of gastrointestinal malignancies. The purpose of this study is to determine the prognostic significance of PET standardized uptake values (SUV) in esophageal cancer treated with chemoradiotherapy (CRT).
Methods: An IRB approved esophageal cancer database was queried for patients who completed treatment for esophageal cancer with CRT between 2006 and 2010. Patients were included in the analysis if they had nonmetastatic esophageal cancer that completed definitive or preoperative CRT and had pre- and post-CRT PET scans. Patients treated with induction chemotherapy were excluded. The pre-and post-CRT SUV maximum values were obtained. Univariate analysis for overall survival (OS) was performed with Kaplan-Meier and log-rank analysis or hazard ratio model. Multivariate analysis (MVA) for OS was performed with a Cox proportional hazard ratio model.
Results: We identified 77 patients who met inclusion criteria with a median followup of 16 months (range 4 - 43 months). Univariate analysis demonstrated that post-CRT SUV max and percent change SUV max were prognostic for OS, while pre-CRT SUV was not prognostic. In addition, there were no deaths in patients with a post-CRT SUV max of ≤3. MVA demonstrated that only post-CRT SUV max (HR 1.401; 95% CI: 1.061-1.850) was prognostic for OS, while age, gender, surgery, histology, tumor length and stage, were not.
Conclusions: Our series demonstrates that post-CRT maximum SUV was the strongest predictor of survival in esophageal cancer while pre-CRT SUV was not. Percent change SUV max was prognostic on univariate analysis but not on multivariate analysis. Prospective studies to evaluate the role of post-CRT SUV in the management of esophageal cancer are needed.