alexa Posterior Reversible Encephalopathy Syndrome During Ind
ISSN: 2165-7831

Journal of Blood & Lymph
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Case Report

Posterior Reversible Encephalopathy Syndrome During Induction Treatment of Philadelphia Positive Acute Lymphoblastic Leukemia in an Adult Patient: First Case Report and Literature Review

Juliette Reure1*, Frederic Peyrade1, Christine Lebrun-Frenay2, Jean Dellamonica3, Salvatore Caruso4, Esma Saada1, Valentine Richez1, Sophie Raynaud5, Antoine Thyss1 and Lauris Gastaud1

1Centre Antoine Lacassagne Nice, France

2Service Neurologie, CHU Nice, France

3Réanimation médicale, CHU Nice, France

4Oncologie Médicale, CH Draguignan, France

5Laboratoire d’onco-hématologie, CHU Nice, France

*Corresponding Author:
Juliette Reure
Centre Antoine Lacassagne Nice
France
Tel: +33637966007
E-mail: [email protected]

Received date: August 13, 2015; Accepted date: September 10, 2015; Published date: September 15, 2015

Citation: Reure J, Peyrade F, Lebrun-Frenay C, Dellamonica J, Caruso S, Saada E, Richez V, Raynaud S, Thyss A, Gastaud L (2015) Posterior Reversible Encephalopathy Syndrome During Induction Treatment of Philadelphia Positive Acute Lymphoblastic Leukemia in an Adult Patient: First Case Report and Literature Review. J Blood Lymph 5:141.doi:10.4172/2165-7831.1000141

Copyright: © 2015 Reure J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical and radiological entity. The circumstances of occurrence are numerous and the pathophysiology is unclear. The main theory is related to the onset of hypertension leading to the deterioration of the cerebral autoregulation. This is an acute or subacute syndrome, often preceded by convulsive episodes. Symptoms are headaches, impaired consciousness, and vomiting or visual disturbances. The brain Magnetic Resonance Imaging (MRI) is the gold standard and highlights evidences of hyperintensities on T2 (bilateral, symmetrical, reversible, and predominantly posterior). Several cases have been reported as a complication during the treatment of childhood acute lymphoblastic leukemia (ALL), but few cases have been published in adult patients and especially in Philadelphia positive ALL. We report the first adult case of Philadelphia positive ALL with development of PRES after induction therapy.

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