Postoperative Biological and Physiological Gastrointestinal Changes after Whipple Procedure
Daniel Timofte*, Ionescu Lidia and LÄcrÄmioara Ochiuz
3rd Surgical Unit, St. Spiridon Hospital, Bd. IndependenÈei, No 1700111, Iasi, Romania
- *Corresponding Author:
- Daniel Timofte, MD, PhD
3rd Surgical Unit, St. Spiridon Hospital
Bd. IndependenÈei, No 1700111, Iasi, Romania
Tel: +40 (0) 731 46 00 00
Fax: +40 (0) 232 21 77 81
E-mail: [email protected]
Received Date: July 12, 2016; Accepted Date: August 20, 2016; Published Date: August 26, 2016
Citation: Timofte D, Ionewscu L, Ochiuz L. Postoperative Biological and Physiological Gastrointestinal Changes after Whipple Procedure. Journal of Surgery [Jurnalul de chirurgie]. 2016; 12(3): 95-99 DOI:10.7438/1584-9341-12-3-1
Copyright: © 2016 Timofte D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the last years there was an increased interest towards the pancreatic cancer, especially considering its growing incidence (rapidly becoming the fifth cause of death by cancer in the developed countries), lack of any sustainable markers and/or risk factors and the chilling fact that almost 95% of the patients with this disorder are presenting to the hospital in the advanced and unresectable stages. Even more, although known and developed for almost 70 years, the surgical approach for the pancreatic cancer is a subject of debate because its efficacy and postoperative biological changes. It is known that the most common surgery in chronic pancreatitis and pancreatic cancer is represented by the Whipple pancreatico duodenectomy. Still, after an extended resection and reconstruction of the upper gastrointestinal tract, it seems that the digestive physiology can be disrupted. In this way, in the present mini-review we will describe some postoperative gastrointestinal biological and physiological changes after Whipple procedure, by mainly focusing on the gastrointestinal motility, bone demineralization, dumping and re-resection, as well as on the affected pancreatic function, postoperative weight loss and remnant pancreatic fibrosis and how the management of this related pathological aspects can be applied in these cases.