Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple CancersMarie Aimée Gloria Munezero Butorano1*, Gennaro Baldino1, Giulia Orlandini2, Clelia Miracco1 and Luigi Pirtoli2
- *Corresponding Author:
- Marie Aimée Gloria Munezero
Sezione di Anatomia Patologic,
Policlinico Santa Maria alle Scotte 6
53100 Siena, Italy
E-mail: [email protected]
Received date: December 08, 2014; Accepted date: December 24, 2014; Published date:December 26, 2014
Citation: Butorano MAGM, Baldino G, Orlandini G, Miracco C, Pirtoli L (2015) Postradiation Osteoblastic Osteosarcoma in the Iliac Region: Report of a Case with Multiple Cancers. J Cytol Histol 6:297. doi:10.4172/2157-7099.1000297
Copyright: © 2015 Butorano MAGM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although rare, osteosarcoma is the most frequent post-radiation second malignancy of the bone. We present a case of an osteoblastic osteosarcoma that occurred in a woman with a history of two neoplasms, as an example of multiple treatment-associated neoplasms. In fact, prior to the development of this osteosarcoma, our patient had been diagnosed with a breast carcinoma 24 years earlier, which had been treated by quadrantectomy, followed by radiotherapy, but it had recurred after 7 years. Thus, the patient had undergone mastectomy, followed by 4 years of tamoxifen. Then, 14 years later, she developed the second tumor, an endometrial adenocarcinoma, which was treated by surgery and adjuvant radiotherapy. Afterwards, a neoplasm developed in the pelvic bones, which histologically proved to be an osteosarcoma. Athough considered low, there is some risk of developing an endometrial cancer after tamoxifen protracted therapy. Since germline mutation analyses for p53 and RB1 resulted negative in our case, Thus, the treatment could have played a prominent role in our patient.