alexa Potent Anti-Malaria Salts, Co-Crystals and Derivatives

Journal of Pharmacological Reports
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Research Article

Potent Anti-Malaria Salts, Co-Crystals and Derivatives of Aminoquinolines with Hydroxyaromatic Acids

Baruah JB1*, Khakhlary P1, Holland S2 and van Zyl RL2

1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, Assam, India

2Pharmacology Division, Department of Pharmacy and Pharmacology, Faculty of Health Sciences; WITS Research, Institute for Malaria (WRIM), University of the Witwatersrand, South Africa

*Corresponding Author:

Baruah JB
Department of Chemistry
Indian Institute of Technology Guwahati
Guwahati 781 039, Assam, India
Tel: +91 361 258 2311
E-mail: [email protected]

Received Date: February 04, 2016;Accepted Date: March 04, 2016; Published Date: March 08,2016

Citation: Baruah JB, Khakhlary P, Holland S, Zyl VRL (2016) Potent Anti-Malaria Salts, Co-Crystals and Derivatives of Aminoquinolines with Hydroxyaromatic Acids.J Pharma Reports 1:111. doi:10.4172/jpr.1000111

Copyright: © 2016 Baruah JB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antimalarial activities of salts of aminoquinolines with hydroxyaromatic acids were found to be higher than the parent components. The IC50 values of the salts were in the range of 5.9-20.3 μM against the chloroquine-resistant strain. Antimalarial actions on the parasites were found to be independent of iron chelation, inhibition of haemozoin formation, as well as independent of the anti-oxidant activity of the salts. A covalently linked amide containing compound N-(quinolin-8-yl)-2-(quinolin-8-yloxy)acetamide was identified to have potency similar to the other salts studied in the article.

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