alexa Potential Antimicrobial Activities of Probiotic Lactoba
ISSN: 2329-8901

Journal of Probiotics & Health
Open Access

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Research Article

Potential Antimicrobial Activities of Probiotic Lactobacillus Strains Isolated from Raw Milk

Eid R1, Jakee JE2, Rashidy A1, Asfour H1, Omara S3, Kandil MM3, Mahmood Z4, Hahne J5 and Seida AA2*
1Animal Reproduction Research Institute, Giza, Egypt
2Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Cairo University, Egypt
3Department of Microbiology and Immunology, National Research Center, Cairo, Egypt
4Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany
5Institute of Cancer Research, London, England
*Corresponding Author : Seida AA
Microbiology and Immunology Department
Faculty of Veterinary Medicine, Cairo University
Giza, Egypt
Tel: 00201154940072
Email: [email protected]
Received: January 25, 2016 Accepted: February 08, 2016 Published: February 15, 2016
Citation: Eid R, Jakee JE, Rashidy A, Asfour H, Omara S, et al. (2016) Potential Antimicrobial Activities of Probiotic Lactobacillus Strains Isolated from Raw Milk. J Prob Health 4: 138. doi:10.4172/2329-8901.1000138
Copyright: © 2016 Eid R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Bacteriocin are highly specific antibacterial proteins which are produced by strains of specific bacteria and showed broad range of antibacterial activity against some mastitis pathogens (S. aureus, E. coli, Y. enterocolitica, S. uberis and S. xylosus). Bacteriocin producing Lactobacillus species were isolated from raw cow, buffalo and, goat milk samples focusing Lactobacillus sp isolated from raw cow milk focusing on their safety, antimicrobial properties and further was purified by gel filtration (Sephadex G-100 column). The molecular weight of the purified bacteriocin was varied between 3-30 kDa, showed high thermal stability (up to 100°C) and was active over wide range of pH (3 to 10). The study revealed the possibility of using bacteriocin as producing lactobacilli antimicrobial agent to treatment some mastitis pathogens.


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