alexa Potential Anti-Microbial, Anti-Inflammatory and Anti-Oxidant Activities of Haplophyllum tuberculatum Growing in Libya
ISSN: 2472-0992

Journal of Pharmacognosy & Natural Products
Open Access

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Research Article

Potential Anti-Microbial, Anti-Inflammatory and Anti-Oxidant Activities of Haplophyllum tuberculatum Growing in Libya

Omar M Sabry1*, Abeer M El Sayed1 and Amany A Slee2

1Pharmacognosy Department, College of Pharmacy, Cairo University, Egypt

2Department of Pharmacology, National Research Centre, Cairo, Egypt

*Corresponding Author:
Omar M Sabry
Pharmacognosy Department
Faculty of Pharmacy, Cairo University
Kasr El-Einy Street, 11562, Cairo, Egypt
Tel: +20224013542

Received date: January 09, 2016; Accepted date: February 16, 2016; Published date: February 22, 2016

Citation: Sabry OM, EI Sayed AM, Slee AA (2016) Potential Anti-Microbial, Anti-Inflammatory and Anti-Oxidant Activities of Haplophyllum tuberculatum Growing in Libya. J Pharmacogn Nat Prod 2:116. doi: 10.4172/2472-0992.1000116

Copyright: © 2016 Sabry OM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Ethanolic extract of the aerial parts of Haplophyllum tuberculatum demonstrated an efficient anti-fungal activity against Aspergillus fumigates, Geotricum candidum and Syncephalastrum racemosum with (MIC 0.49, 0.12 and 1.95 μg/ml). It also presented 75% potency as antibacterial agent on Staphylococcus aureus and Escherichia coli (MIC 1.95 and 15.63 μg/ml). Volatile oil of the aerial parts demonstrated significant antibacterial effect against Enterococcus faecalis and Lactobacillus acidophilus (MIC 1.95 and 0.98 μg/ml). The essential oils from aerial parts and flowers exhibited a remarkable acute anti-inflammatory activity against carrageenan induced oedema in rats 9.52 and 8.56 which were found to be comparable to the standard drug at the selected dose. The ethanolic extract of the aerial parts exhibited significance anti-oxidant activity (98%) as compared to vitamin E.

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