alexa Potential Application of Gold Nanostructures in Photodynamic Therapy
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Potential Application of Gold Nanostructures in Photodynamic Therapy

Hemant Kumar1*, Arvind Kumar2, Devendra Kumar Gangwar3, Prabin Kumar4, Gajendra Singh5 and Udit Soni6

1University of Hyderabad, School of Chemistry, Hyderabad -500046, India

2Department of Zoology, Bareilly College Bareilly, Bareilly, M. J. P. Rohilkhand University, Bareilly-23001, India

3Department of Chemistry, Vardhaman College, M. J. P. Rohilkhand University, Bijnor-246701, India

4Department of Chemistry, Sri Guru Tegh Bahadur Khalsa College, University of Delhi, Delhi-07, India

5Department of Chemistry, Deshbandhu College, University of Delhi, Delhi-19, India

6Department of Biotechnology, Teri University, Vasant Kunj, New Delhi-70, India

*Corresponding Author:
Hemant Kumar
University of Hyderabad
School of Chemistry, Hyderabad -500046, India
Tel: 91403010500
E-mail: [email protected]

Received Date: December 13, 2015 Accepted Date: Janaury 06, 2016 Published Date: January 25, 2016

Citation: Kumar H, Kumar A, Gangwar DK, Kumar P, Singh G, et al. (2016) Potential Application of Gold Nanostructures in Photodynamic Therapy. J Nanomed Nanotechnol 7:349. doi:10.4172/2157-7439.1000349

Copyright: © 2016 Kumar H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this manuscript we report the synthesis of gold nanostructures (G2) via seed-mediated growth method using CTAB as the surfactant, their size and morphology have been elucidated by TEM and DLS. The UV-visible absorption spectra of G2NPs showed a more intense peak at 680 nm and less intense peak at 520 nm indicating, formation of gold nanorods in majority. In case of G2 nanostructures the longitudinal LSPR peak could be tunable as a function of their aspect ratio. The gold nanostructures conjugated with a photosensitizer (G2-PS NPs) were applied in Photodynamic Therapy (PDT). These G2-PS NPs stably-dispersed in aqueous medium and were characterized by optical studies. Cell viability studies demonstrated that only PS conjugated NPs (G2-PS NPs) could only generate cytotoxic singlet oxygen. The results indicate the promise of G2-PS NPs as delivery agents in photodynamic therapy

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