Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis
|Wonhwa Lee1,2 and Jong-Sup Bae1*|
|1College of Pharmacy, Research Institute of Pharmaceutical Sciences, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea|
|2Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea|
|Corresponding Author :||Jong-Sup Bae, Ph.D.
College of Pharmacy
Research Institute of Pharmaceutical Sciences
School of Medicine, Kyungpook National University
80 Daehak-ro, Buk-gu, Daegu 702-701, Republic of Korea
E-mail: [email protected]
|Received August 07, 2012; Accepted August 10, 2012; Published August 13, 2012|
|Citation:Lee W, Bae JS (2012) Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis. Biochem Pharmacol 1:e129. doi:10.4172/2167-0501.1000e129|
|Copyright: © 2012 Lee W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
High Mobility Group Box 1 (HMGB1) is highly conserved through evolution, and has 99% identity among all mammals. Out of its 215 amino acids, only two residues are substituted in the rodent and human versions. HMGB1 was originally described as a nuclear protein that binds DNA, and functions as a co-factor that is required for transcriptional regulation and gene expression.