alexa Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Editorial

Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis

Wonhwa Lee1,2 and Jong-Sup Bae1*
1College of Pharmacy, Research Institute of Pharmaceutical Sciences, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea
2Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea
Corresponding Author : Jong-Sup Bae, Ph.D.
College of Pharmacy
Research Institute of Pharmaceutical Sciences
School of Medicine, Kyungpook National University
80 Daehak-ro, Buk-gu, Daegu 702-701, Republic of Korea
Tel: 82-53-950-8570
Fax: 82-53-950-8557
E-mail: [email protected]
Received August 07, 2012; Accepted August 10, 2012; Published August 13, 2012
Citation:Lee W, Bae JS (2012) Potential Herbal Therapy of HMGB1-Targeting Agent in Sepsis. Biochem Pharmacol 1:e129. doi:10.4172/2167-0501.1000e129
Copyright: © 2012 Lee W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

High Mobility Group Box 1 (HMGB1) is highly conserved through evolution, and has 99% identity among all mammals. Out of its 215 amino acids, only two residues are substituted in the rodent and human versions. HMGB1 was originally described as a nuclear protein that binds DNA, and functions as a co-factor that is required for transcriptional regulation and gene expression.

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