alexa Potential New Markers of Inflammation-Induced Renal Injury Subside when Endotoxin Tolerance Develops in Humans | OMICS International | Abstract
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Potential New Markers of Inflammation-Induced Renal Injury Subside when Endotoxin Tolerance Develops in Humans

Rosalinde Masereeuw2*, Annelies Draisma1, Suzanne Heemskerk2, Martijn PWJM Bouw1, Coby Laarakkers3, Johannes G van der Hoeven1 and Peter Pickkers1

1Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

2Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

3Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

*Corresponding Author:
Rosalinde Masereeuw
Department of Pharmacology and Toxicology (149)
Radboud University Nijmegen Medical Centre
PO box 9101, 6500 HB
Nijmegen, the Netherlands
Tel: +31-24-3613730
Fax: +31-24-3614214
E-mail: [email protected]

Received Date: January 24, 2013; Accepted Date: March 11, 2013; Published Date: March 13, 2013

Citation: Masereeuw R, Draisma A, Heemskerk S, Bouw MP, Laarakkers C, et al. (2013) Potential New Markers of Inflammation-Induced Renal Injury Subside when Endotoxin Tolerance Develops in Humans. J Proteomics Bioinform 6:058-064. doi: jpb.1000262

Copyright: © 2013 Masereeuw R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: Cytokines play an important role in the development of renal injury during sepsis. Because of its high mortality rate, early detection of inflammation-induced renal injury is of critical importance.

Methods: We used Surface enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI- -TOF MS), to search for new biomarkers for early renal injury during acute systemic inflammation, and after development of endotoxin tolerance in humans in vivo.

Results: Repeated LPS administrations induced a 33 ± 7% decrease in glomerular filtration rate (p=0.02) on day 2, and an increase in serum creatinine of 11 ± 3% (p=0.002) on day 3, which was associated with the appearance of 15 peak intensities in the urinary protein profile, including an increase in ß2-microglobuline levels (p=0.04), 6 hours after the first LPS administration. Four of the 15 peak intensities on day 1 correlated with serum creatinine levels on day 3; 3950, 4445, 6723 and 7735 m/z (r=0.91, 0.97, 0.94, 0.87; p=0.03; 0.01; 0.02 and 0.05, respectively). With the development of LPS tolerance, renal function restored, reflected by a decrease in serum creatinine and ß2-microglobuline to baseline levels (p=0.2 and 0.4, respectively, between day 1 and 5), and by attenuated peak intensities in the urinary protein profile (p<0.0001 for all 15 peak intensities).

Conclusion: Renal injury occurs during repeated endotoxemia and can be predicted by new urinary markers using proteome research. The four markers that correlated with the extent of renal injury may represent potential new biomarkers for renal injury and need further identification. The inflammation-induced renal injury subsided, when LPS tolerance developed after 5 consecutive days of LPS.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7