Potential therapeutic Strategies and Its Application in Correcting Birth Defects, Craniosynostosis, Neurological Disorders and Other Diseases
|Mayadhar Barik1*, Minu Bajpai2, Arun Malhotra1, Samantaray JC3 and Dwiedi SN4|
|1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India|
|2Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110 029, India|
|3Department of Microbiology, All India Institute of Medical Sciences, New Delhi-110 029, India|
|4Department of Biostatistics, All India Institute of Medical Sciences, New Delhi-110 029, India|
|Corresponding Author :||Mayadhar Barik
Department of Nuclear Medicine
All India Institute of Medical Sciences
Ansari Nagar, P.O. Box-110029, New Delhi, India
Tel: 0011-2659-3210, 91-9013082255
Fax: 91-11-26588531, 26588663
E-mail: [email protected], [email protected]
|Received February 28, 2013; Accepted June 14, 2013; Published Jun 21, 2013|
|Citation: Barik M, Bajpai M, Malhotra A, Samantaray JC, Dwiedi SN (2013) Potential therapeutic Strategies and Its Application in Correcting Birth Defects, Craniosynostosis, Neurological Disorders and Other Diseases. J Metabolic Synd 2:122. doi:10.4172/2167-0943.1000122|
|Copyright: © 2013 Barik M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: Gene Therapy (GT) aims to fix a disease linked with genetic abnormality. Gene Therapy (GT) is currently receiving an attention from scientists, clinicians and the general public in an attempt to correct genetic defects. It including with congenital abnormalities, craniosynostosis (syndromic and nonsyndromic), craniofacial deformity, and neurodevelopmental disorders. However, its application is beset with complications partly because of lack of advanced knowledge, research and partly because of vested interest by the society.
Objective: This study is an attempt to highlight some of the major benefits of gene therapy which leads to define the role played by medical informatics in facilitating rational use of gene therapy.
Materials and methods: An attempt was made to review major studies in the international literature to synthesize the potential risks, benefits of gene therapy. We also reviewed the tools and techniques in this field of medical informatics. W hich can be employed for spreading awareness about gene therapy among common people? We developed a conceptual model of matching the key concepts with the current protocols used in the field of medical informatics.
Results: GT offers a new hope for the treatment of birth defects, neurodegenerative disorders like Huntingtons disease. Its application in Parkinsons disease has moved a step closer to acceptance in the wake of its successful double blind clinical trial. The educational media, fall under four categories, viz., audio media, the visual media, the audio-visual and the virtual-media in vitro and vivo. The simulation and animation capabilities of the media are quite helpful in the conceptualization of gene therapy. The audio-visual media are useful for counseling in matter of genetic disorders the public.
Conclusion: Our study suggests that an integrated and holistic approach of medical informatics. It can be highly beneficial for the advanced application of gene therapy in the years to come. G T has become debatable and often controversial because of tendency to use for manipulating the desirable attributes. Moreover, its rational use is likely to benefit the mankind.