alexa Potentiation of Epileptogenic Effect of Isoniazid By Et
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Potentiation of Epileptogenic Effect of Isoniazid By Ethanol Consumption

Gaba BS1*, Mittal SP2, Malik Anupam2 and Modi Akash Kumar2
1Gaba Hospital, Haryana, India
2Department of General Medicine, Gaba Hospital, Haryana, India
Corresponding Author : Gaba BS
Director Gaba Hospital
Haryana, India
Tel: +919416021068
Fax: +91-1732-223724
E-mail: [email protected]
Received May 19, 2013; Accepted July 09, 2013; Published July 12, 2013
Citation: Gaba BS, Mittal SP, Malik Anupam, Kumar MA (2013) Potentiation of Epileptogenic Effect of Isoniazid By Ethanol Consumption. J Clin Case Rep 3:292. doi:10.4172/2165-7920.1000292
Copyright: © 2013 Gaba BS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The incidence of adverse reaction to isoniazid was estimated to be 3.4% in a study done in more than 3000 patients treated withthis drug. The most common adverse effect being rash (2%), fever(1.2%), jaundice (0.6%) and peripheral neuritis (0.6%). If pyridoxine is not given concurrently, the incidence of peripheral neuritis (mostcommonly parasthesias of hands and feet) is the most common adverse reaction to isoniazid and occurs in about 2% of patients receiving 5 mg/kg. Higher doses may result in peripheral neuropathy in around 10-20% of the patients. The prophylactic administration of pyridoxine prevents thedevelopment not only of peripheral neuritis, but also of other neurological adverse effects. Muscle twitching, dizziness, ataxia, parasthesias, stupor and toxic encephalopathy are other manifestationsof the neurotoxicity of isoniazid.


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