PRDM16 in Development and DiseaseDennis R Warner, Robert M Greene and Michele Pisano*
Department of Molecular, Cellular, and Craniofacial Biology University of Louisville Birth Defects Center, Kentucky, USA
- *Corresponding Author:
- Michele Pisano
Department of Molecular
Cellular and Craniofacial Biology
University of Louisville Birth Defects Centre,
University of Louisville, Louisville, Kentucky, USA 40292,
E-mail: [email protected]
Received November 08, 2012; Accepted December 17, 2012; Published December 19, 2012
Citation: Warner DR, Greene RM, Pisano MM (2014) PRDM16 in Development and Disease. Human Genet Embryol 4:121. doi: 10.4172/2161-0436.1000121
Copyright: © 2014 Warner DR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PRDM16 is a member of the PRDM family of transcription co-regulators characterized by a PR domain (positive regulatory domain) that is similar to the SET domain found in lysine histone methyltransferases. Most PRDM proteins also contain one or more zinc finger domains that can confer direct DNA binding, in addition to other domains that mediate binding to additional transcription factors and cofactors. PRDM16 was originally identified from studies of (1;3)(p36;q21)-positive leukaemia’s but has subsequently been implicated in several developmental processes, including differentiation of muscle cell precursors into brown adipocyte fat cells. Such differentiation, regulated in part by the enzyme tyrosine-protein kinase-2 (Tyk2), has gained recent attention as a means to reduce obesity via manipulating the production of TYK2 and/or PRDM16. In addition, PRDM16 is also involved in hematopoietic stem cell maintenance and craniofacial development. This review focuses on our current understanding of the role of PRDM16 in each of these processes and highlights some of the challenges for future studies.