alexa Pre Filter Hemodiafiltration with Heparin-Dose Minimization: A Safe and Effective Technique | OMICS International| Abstract
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Short Communication   
  • J Nephrol Ther 2019, Vol 9(4): 336

Pre Filter Hemodiafiltration with Heparin-Dose Minimization: A Safe and Effective Technique

Sergio VO*, Sergio VO1*, Mónica SC1, Evelyn CDR2, Raúl I2, Enzo VJ1 and Héctor PGG1
1Department of Nephrology, National Institute of Cardiology, National Autonomous University of Mexico, Mexico City, Mexico
2Department of Hematology, National Institute of Cardiology, National Autonomous University of Mexico, Mexico City, Mexico
*Corresponding Author : Sergio VO, Department of Nephrology, National Institute of Cardiology, National Autonomous University of Mexico, Mexico City, C.P. 14080, Mexico, Tel: +52 (55) 5573 2911, Email: [email protected]

Received Date: Sep 16, 2019 / Accepted Date: Oct 10, 2019 / Published Date: Oct 15, 2019

Abstract

Background: Unfractionated heparin (UFH) administered during hemodialysis (HD) has cumulative adverse effects; hence the importance of using the lowest possible dose and avoid overdosing. Methods: We analyzed 30 patients with chronic hemodiafiltración (HDF) treatment divided in 3 groups: pos filter HDF with heparin standard impregnation dose (27 ± 6.5 IU/kg), HDF pos filter with impregnation low dose (15 ± 4.2 IU/ kg); in both groups, heparin impregnation and maintenance were given, and a third group HDF pre-dilution only with heparin impregnation dose (27 ± 12.8 IU/kg). We measured partial thromboplastin time (aPTT) and serum heparin levels at 30 and 190 min, in the three groups. Results: HDF pre-dilution group received a significantly lower total dose than the other 2 groups; 1750 vs. 2650/3444 UI/Kg (p<0.001), maintaining 30 min aPTT target (55.6 ± 43.4) as aPTT 190 min (44.4 ± 30.3), as well as effectiveness of the treatment (substitution volume of 51.4 ± 11.8 L, Ktv 1.38 ± 0.3). The other two groups reached aPTT 30 min target, but decreased towards the end of HDF sessions (aPTT 190 min). HDF pre-dilution did not increase clot formation (p<0.678). There were no major coagulation or bleeding events in any of the HDF sessions. Conclusion: Pre dilution HDF with only impregnation heparin is a safe and effective method; after the amplification and reproduction of our results, it could represent an alternative treatment that minimizes UFH doses in order to reduce the associated adverse events.

Keywords: Heparin; Hemodialysis; Blood; Dialysis

Citation: Sergio VO, Mónica SC, Evelyn CDR, Raúl I, Enzo VJ, et al. (2019) Pre Filter Hemodiafiltration with Heparin-Dose Minimization: A Safe and Effective Technique. J Nephrol Ther 9: 336.

Copyright: © 2019 Sergio VO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top