alexa Prediction of Major Histocompatibility Complex Binding Peptides and Epitopes from Fatty-Acid-Binding Protein of the Human Blood Fluke Schistosoma Japonicum
ISSN: 2153-0769

Metabolomics:Open Access
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Research Article

Prediction of Major Histocompatibility Complex Binding Peptides and Epitopes from Fatty-Acid-Binding Protein of the Human Blood Fluke Schistosoma Japonicum

Somnath Waghmare1* and Ramrao Chavan2

1Department of Zoology, Nowrosjee Wadia College of Arts and Science, Pune, India

2Department of Zoology, Dr.Babasaheb Ambedkar Marathawada University, Aurangabad, India

*Corresponding Author:
Dr. Somnath Waghmare
Assistant Professor, Department of Zoology
Nowrosjee wadia College of Arts and Science, Pune-1, India
Tel: +91 9881926518
E-mail: [email protected]

Received date: May 07, 2012; Accepted date: June 21, 2012; Published date: June 23, 2012

Citation: Waghmare S, Chavan R (2012) Prediction of Major Histocompatibility Complex Binding Peptides and Epitopes from Fatty-Acid-Binding Protein of the Human Blood Fluke Schistosoma Japonicum. Metabolomics 2:113. doi: 10.4172/2153-0769.1000113

Copyright: © 2012 Waghmare S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Schistosoma japonicum are blood flukes of humans that cause chronic, highly debilitating diseases involving extensive liver damage. In the present study, fatty-acid-binding protein of the human blood fluke Schistosoma japonicum is being used to find out highly suitable MHC binding peptides and epitopes. MHC molecules are cell surface proteins, which take active part in host immune reactions and involvement of MHC class in response to almost all antigens and it give effects on specific sites. Predicted MHC binding regions acts like red flags for antigen specific and generate immune response against the parent antigen. So a small fragment of antigen can induce immune response against whole antigen. This theme is implemented in designing subunit and synthetic peptide vaccines. Fragments identified through this approach tend to be high efficiency binders, in which larger percentage of their atoms are directly involved in binding as compared to larger molecules. Binding ability prediction of peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from fatty-acid-binding protein of the human blood fluke Schistosoma japonicum.

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