Prediction of Membrane Spanning ÃÂ² Strands in Bacterial Porins by Using Wavelet Support Vector Machine Algorithm
Information Engineering and Technology Department, South China Normal University, Guangdong Foshan, China
- *Corresponding Author:
- Guang-ming Xian
Information Engineering and Technology Department
South China Normal University
Guangdong Foshan, China, 528225
E-mail: [email protected]
Received Date: May 12, 2012; Accepted Date: June 20, 2012; Published Date: June 26, 2012
Citation: Xian GM (2012) Prediction of Membrane Spanning β Strands in Bacterial Porins by Using Wavelet Support Vector Machine Algorithm. J Proteomics Bioinform 5: 135-139. doi: 10.4172/jpb.1000225
Copyright: © 2012 Xian GM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
For accurate prediction of transmembrane β strands in bacterial porins, we proposed a wavelet support vector machine (WSVM) algorithm to predict the transmembrane β strands in bacterial porins based on the application of WSVM algorithm. The method was applied to all the five porins of known structure (three training proteins, porins from Escherichia coli, Rhodobacter capsulatus and Rhodopseudomonas blastic and two test proteins, porin from Klebsiella pneumoniae and Comamonas acidovorans). For all the five proteins the WSVM method predictived the transmembrane strands in bacterial porins to an average accuracy 84.9%, a higher predictive level than SVM (81.6%) and RNFNN (78.8%) methods. The best test result of the SVM is the precictor with wavelet kernel, which is 84.9% better than other three SVM kernel function of the Gaussian RBF kernel, Polynomial kernel as well as Linear kernel that average 81.6%, 80.3%, and 79.8%, respectively. The experimental results demonstrate the efÃ¯Â¬Âcacy of the proposed WSVM method.