alexa Predictive Activity Modeling of 2-Substituent-1H-Benzimidazole-4- Carboxamide Derivatives against Enteroviruses using QSAR Approach | OMICS International| Abstract
ISSN: 2157-7420

Journal of Health & Medical Informatics
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  • Research Article   
  • J Health Med Informat 2015, Vol 6(2): 187
  • DOI: 10.4172/2157-7420.1000187

Predictive Activity Modeling of 2-Substituent-1H-Benzimidazole-4- Carboxamide Derivatives against Enteroviruses using QSAR Approach

Mukesh C Sharma*
School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore-452 001, Madhya Pradesh, India
*Corresponding Author : Mukesh C Sharma, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore-452 001, Madhya Pradesh, India, Tel: 91-731-216005, Email: [email protected]

Received Date: Mar 11, 2015 / Accepted Date: Apr 17, 2015 / Published Date: Apr 22, 2015

Abstract

Abstract

The present study was focused on development of the potential compound containing 2-substituent-1Hbenzimidazole- 4-carboxamide derivatives against enteroviruses using QSAR studies. We discussed the twodimensional QSAR studies of 2-substituent-1H-benzimidazole-4-carboxamide analogues to elucidate the structural properties required for enteroviruses activity. The 2D-QSAR studies were performed using multiple linear regressions, giving square of correlation coefficient (r2)=0.7458, cross validated squared correlation coefficient (q2)=0.7128 and predictable ability (pred_r2)=0.7092. The present study reveals that presence of less bulky group at R1 position of benzimidazole scaffold increase the enteroviruses activity. We hope that the current study provides better insight into the designing and development of more potent benzimidazole-4-carboxamide inhibitors as enteroviruses drug in the future.

Keywords: Benzimidazole, Enteroviruses, 2D-QSAR, Multiple linear regressions

Citation: Sharma MC (2015) Predictive Activity Modeling of 2-Substituent-1HBenzimidazole-4-Carboxamide Derivatives against Enteroviruses using QSAR Approach. J Health Med Informat 6:187. Doi: 10.4172/2157-7420.1000187

Copyright: © 2015 Sharma MC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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