Predictive Diagnostic Tools for the Development of New Onset Diabetes Mellitus after Transplantation: An Overview
- *Corresponding Author:
- Phuong-Thu T Pham
Clinical Associate Professor of Medicine
Director of Outpatient Services
Department of Medicine, Nephrology Division
Kidney Transplant Program
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095
E-mail: [email protected]
Received Date: July 25, 2011; Accepted Date: August 02, 2011; Published Date: September 26, 2011
Citation: Pham PT, Pham PC (2011) Predictive Diagnostic Tools for the Development of New Onset Diabetes Mellitus after Transplantation: An Overview. J Transplant Technol Res 1: 103e. doi: 10.4172/2161-0991.1000103e
Copyright: © 2011 Pham PT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
New onset diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. NODAT has been reported to occur in 2% to 53% of all solid organ transplants. Kidney transplant recipients who develop NODAT have variably been reported to be at increased risk of fatal and nonfatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Limited clinical studies in liver, heart, and lung transplants similarly suggested that NODAT has an adverse impact on patient and graft outcomes. Early detection and management of NODAT must, therefore, be integrated into the treatment of transplant recipients. Studies investigating the best predictive tool for identifying patients at risk for developing NODAT early after transplantation, however, are lacking. The clinical predictive values of fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), and A1C in assessing the risk for the manifestation of NODAT are herein discussed.