Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients
|Berezin AE1* and Lisovaya OA2|
|1Internal Medicine Department, State Medical University, Zaporozhye, Ukraine|
|2District Hospital #6, Zaporozhye, Ukraine|
|*Corresponding Author :||Alexander E Berezin
Internal Medicine Department
State Medical University
E-mail: [email protected]
|Received October 26, 2013; Accepted January 28, 2014; Published February 07, 2014|
|Citation: Berezin AE, Lisovaya OA (2014) Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients. Intern Med S11:006. doi:10.4172/2165-8048.S11-006|
|Copyright: © 2014 Berezin AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aim: The aim of the study was to investigate the predictive value of serial measurements of circulating vascular endothelial growth factor-1 level in hypertensive patients after ischemic stroke.
Methods: 102 patients with mild to moderate arterial hypertension within 3 weeks after ischemic stroke were included in the study. Patients were followed-up for 12 months with 3 month intervals. The circulating of VEGF-1 level was assessed at baseline. Clinical interviews were conducted every 3 months for 1 year after receiving blood samples. As a clinical point we determined following cardiovascular outcomes: recurrent stroke or TIA, ischemic heart disease, sudden death, diabetes mellitus, cardiovascular events, including chronic heart failure and the need for hospitalization for these reasons.
Results: Analysis of obtained outcomes showed that increased VEGF-1 concentration within six months after ischemic stroke has positively associated with incidence of cardiovascular events, when compared with individuals without increased circulating levels of VEGF-1. Adjusted odds ratio for the occurrence of cumulative cardiovascular events in hypertension patients with VEGF-1 concentration at baseline above 403.57 pg/ml was 4.11 (95% CI=2.66- 7.28; P=0.001), when compared with lower concentration of VEGF-1.
Conclusion: In conclusion, we found that incremented circulating vascular endothelial growth factor-1 level was an independent predictor of 1 year cumulative cardiovascular events in hypertensive patients after ischemic stroke.