alexa Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients | OMICS International | Abstract
ISSN: 2165-8048

Internal Medicine: Open Access
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Research Article

Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients

Berezin AE1* and Lisovaya OA2
1Internal Medicine Department, State Medical University, Zaporozhye, Ukraine
2District Hospital #6, Zaporozhye, Ukraine
*Corresponding Author : Alexander E Berezin
Internal Medicine Department
State Medical University
Zaporozhye, Ukraine
Tel: +380612729607
Fax: +380612729607
E-mail: [email protected]
Received October 26, 2013; Accepted January 28, 2014; Published February 07, 2014
Citation: Berezin AE, Lisovaya OA (2014) Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients. Intern Med S11:006. doi:10.4172/2165-8048.S11-006
Copyright: © 2014 Berezin AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: The aim of the study was to investigate the predictive value of serial measurements of circulating vascular endothelial growth factor-1 level in hypertensive patients after ischemic stroke.
Methods: 102 patients with mild to moderate arterial hypertension within 3 weeks after ischemic stroke were included in the study. Patients were followed-up for 12 months with 3 month intervals. The circulating of VEGF-1 level was assessed at baseline. Clinical interviews were conducted every 3 months for 1 year after receiving blood samples. As a clinical point we determined following cardiovascular outcomes: recurrent stroke or TIA, ischemic heart disease, sudden death, diabetes mellitus, cardiovascular events, including chronic heart failure and the need for hospitalization for these reasons.
Results: Analysis of obtained outcomes showed that increased VEGF-1 concentration within six months after ischemic stroke has positively associated with incidence of cardiovascular events, when compared with individuals without increased circulating levels of VEGF-1. Adjusted odds ratio for the occurrence of cumulative cardiovascular events in hypertension patients with VEGF-1 concentration at baseline above 403.57 pg/ml was 4.11 (95% CI=2.66- 7.28; P=0.001), when compared with lower concentration of VEGF-1.
Conclusion: In conclusion, we found that incremented circulating vascular endothelial growth factor-1 level was an independent predictor of 1 year cumulative cardiovascular events in hypertensive patients after ischemic stroke.

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