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ISSN: 2167-0943

Journal of Metabolic Syndrome
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  • Research Article   
  • J Metabolic Synd 2017, Vol 6(4): 235
  • DOI: 10.4172/2167-0943.1000235

Predictors of Insulin Resistance in Obesity and Type 2 Diabetes Mellitus - The Role of Magnesium

Soetkin Milbouw1#, Julie Verhaegen1#, An Verrijken1, Tom Schepens2, Benedicte Y De Winter3, Luc F Van Gaal1,3, Kristien J Ledeganck3*# and Christophe EM De Block1,3#
1Department of Endocrinology, Diabetology and Metabolic disease of the Antwerp University Hospital, , Wilrijkstraat 10, 2650 Edegem, Belgium
2Department of Anesthesiology and Critical Care Medicine, Antwerp University Hospital, Edegem, Belgium
3Laboratory of experimental medicine and pediatrics, University of Antwerp, Antwerp, Belgium
#Contributed equally to this work
*Corresponding Author : Kristien J Ledeganck, University of Antwerp, Universiteitsplein 1, T3.34, 2610 Antwerp, Belgium, Tel: 0032(0)32652573, Email: [email protected]

Received Date: Nov 21, 2017 / Accepted Date: Nov 27, 2017 / Published Date: Dec 18, 2017

Abstract

Objectives: Hypomagnesaemia and insulin resistance are two major clinical problems, with intertwining pathophysiology. We aimed to explore this association in obese patients and in non-insulin-treated patients with type 2 diabetes mellitus (T2DM).
Methods: Subjects were recruited from the outpatient diabetes/obesity clinic of the Antwerp University Hospital. The population (N=2731) consists of 2 subject groups with different degrees of insulin resistance and insulin secretory potential: 1) overweight (Body Mass index (BMI) ≥ 25 kg/m² and <30 kg/m²) and obese (BMI ≥ 30 kg/m²) subjects, 2) adult T2DM patients. Hypomagnesaemia was defined as serum magnesium <1.7 mg/dl. Insulin resistance was estimated using the Homeostasis model assessment (HOMA-IR; cut-off point 2.82).
Results: Hypomagnesaemia was present in 6.1% of the entire population. Patients with hypomagnesaemia had more visceral adipose tissue (VAT), and a higher HOMA-IR. They suffered more from the metabolic syndrome and T2DM. Patients with a HOMA-IR<2.82 were younger, had lower BMI and less VAT. They suffered less from hypomagnesaemia. Hypomagnesaemia was more prevalent in T2DM patients than in obese subjects without T2DM. Although serum magnesium and HOMA-IR were negatively correlated, logistic regression analysis showed that magnesium was not a significant predictor for HOMA-IR.
Conclusions: Despite a significant negative correlation between magnesium and HOMA-IR, magnesium was not retained as a significant determinant of insulin resistance compared to the other predictors in our population of obese subjects and T2DM patients.

Keywords: Hypomagnesaemia; Insulin resistance; Visceral adipose tissue; Obesity; Diabetes mellitus; HOMA-IR; Predictors

Citation: Milbouw S, Verhaegen J, Verrijken A, Schepens T, de Winter BY, et al. (2017) Predictors of Insulin Resistance in Obesity and Type 2 Diabetes Mellitus – The Role of Magnesium. J Metabolic Synd 6: 235. Doi: 10.4172/2167-0943.1000235

Copyright: © 2017 Milbouw S, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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