alexa Predictors of Preeclampsia in Women in the Metformin in
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study

Helen L Barrett1-3*, Marloes Dekker Nitert2,3, H David McIntyre3,4, William M Hague5, Leonie K Callaway1,3 and Janet Rowan6

1Internal Medicine, Royal Brisbane and Women’s Hospital, Herston, Queensland, Australia

2UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia

3School of Medicine, The University of Queensland, St Lucia, Queensland, Australia

4Mater Medical Research Institute, Queensland, Australia

5Robinson Institute and Discipline of Obstetrics & Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia

6National Women’s Health, Auckland City Hospital, Grafton, Auckland, New Zealand

*Corresponding Author:
Helen Barrett
Level 7, UQ Centre for Clinical Research
The University of Queensland, RBWH Campus
Central Drive off Circular Drive
Herston, Queensland, Australia
Tel: +61 7 36468111
Fax: +61 7 3346 5179
E-mail: [email protected]

Received date: May 22, 2014; Accepted date: June 18, 2014; Published date: June 26, 2014

Citation: Barrett HL, Nitert MD, McIntyre HD, Hague WM, Callaway LK, et al. (2014) Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes (Mig) Study. J Diabetes Metab 5:395. doi:10.4172/2155-6156.1000395

Copyright: © 2014 Barrett HL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

 

Abstract

Background: Gestational Diabetes Mellitus (GDM), maternal obesity and pregnancy weight gain are associated with an increased risk of developing Preeclampsia (PE). The aim of this study was to examine the predictors of PE in women commencing pharmacotherapy for GDM in the Metformin in Gestational diabetes trial.

Methods: Descriptive and logistic regression analyses examined the relationship between maternal enrolment characteristics and later development of PE.

Results: 46 (6.3%) of 703 women developed PE. At enrolment ((30 (SD3.2) weeks gestation), women who later developed PE had higher HbA1c (6.14% (95%CI 5.84, 6.45) vs. 5.73% (95%CI 5.67, 5.78), P=0.003), fasting triglycerides (2.93 mmol/L (95%CI 2.57, 3.29) vs. 2.55mmol/L (95%CI 2.47, 2.62), P=0.03) and blood pressure. Their infants were born 9 days earlier (P<0.001) but were otherwise not different. In univariate analysis, the strongest positive predictors for PE were Polynesian ethnicity (OR 2.75 (95%CI 1.48, 5.09), P=0.001), personal or family history of PE (OR 2.65 (95%CI 1.36, 5.16), P=0.004), maternal HbA1c (OR 1.96 (95%CI 1.35, 2.89), P<0.001), triglycerides (OR 1.45 (95%CI 1.07,1.97), P=0.002), and weight gain from early pregnancy (OR 1.09 (95%CI 1.03,1.17), P=0.01). HDL-C was a negative predictor of PE (OR 0.29 (95%CI 0.09, 0.94), P=0.04). Following adjustment for Polynesian ethnicity and personal or family history of PE, and when further adjusted for HbA1c or early pregnancy BMI, these variables remained significant.

Conclusion: Treatment allocation and BMI were not associated with risk of PE. Personal or family history of PE, Polynesian ethnicity, degree of hyperglycemia, maternal triglycerides and weight gain prior to treatment signal increased risk of subsequent PE in women needing pharmacotherapy for GDM.

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