Preferential Mobilization and Egress of Type 1 and Type 3 Innate Lymphocytes in Response to Exercise and HypoxiaIvan NG1, Fairchild TJ2, Greene WK1 and Hoyne GF3,4,5*
- *Corresponding Author:
- Gerard Hoyne
School of Health Sciences
University of Notre Dame Australia, Fremantle
Western Australia, 6959, Australia
Email: [email protected]
Received date: June 09, 2016; Accepted date: August 16, 2016; Published date: August 26, 2016
Citation: Ivan NG, Fairchild TJ, Greene WK, Hoyne GF (2016) Preferential Mobilization and Egress of Type 1 and Type 3 Innate Lymphocytes in Response to Exercise and Hypoxia. Immunome Res 12:123. doi: 10.4172/1745-7580.10000123
Copyright: © 2016 Ivan NG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The study examined the effect of exercise and hypoxia on the mobilization and egress of innate lymphocytes (ILCs) and adaptive T cell populations in the blood. The ILCs have emerged as a critical population of cells in immune regulation at mucosal surfaces in animals and humans. Eleven healthy male subjects performed (i) 45 min of exercise at 50% VO2 peak on a cycle ergometer under normoxia and (ii) hypoxia, or (iii) while resting in hypoxia. Blood samples were obtained pre-exercise, immediately post-exercise and 60 min post-exercise and were analyzed by flow cytometry to examine the type 1 and type 3 ILCs and CD4+ and CD8+ naive and memory cell populations. There was a significant increase in the number of type 1 (NK cells) and type 3 ILC22 cells in the blood in response to exercise under normal oxygen conditions followed by a significant egress of these cells following the cessation of exercise. Exercise performed under hypoxic conditions abrogated the mobilization response of NK cells and ILC22 cells. Type 3 LTi cells were mobilized into the blood only under hypoxic rest conditions. No significant changes were observed when we analysed total CD4+ and CD8+T cell populations or the naive and memory subsets. This study highlights that distinct innate populations are mobilised under different environmental conditions and types of stress.