PreformulationSousa e Silva JP*
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Department of Drug Sciences, University of Porto, Rua Jorge Viterbo Ferreira, 228 4050-313 Porto, Portugal
- *Corresponding Author:
- Sousa e Silva JP
Laboratory of Pharmaceutical Technology
Faculty of Pharmacy, Department of Drug Sciences
University of Porto, Rua Jorge Viterbo Ferreira
228 4050-313 Porto, Portugal
E-mail: [email protected]
Received date: January 22, 2013; Accepted date: January 24, 2013; Published date: January 25, 2013
Citation: Sousa e Silva JP (2013) Preformulation. Pharmaceut Anal Acta 4:e144. doi: 10.4172/2153-2435.1000e144
Copyright: © 2013 Sousa e Silva JP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A square wave voltammetry (SWV) method for the determination of trace amounts of paracetamol at carbon paste electrode modified with managanese (Mn-CPE) is proposed. The results showed that the Mn-CPE exhibited excellent electro catalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained. The concentration of paracetamol and measuring solution pH was investigated. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 6.8×10-10 mol.L-1 with the relative standard deviation of 2.0% (n=7). The sensor was successfully applied to the determination of paracetamol in a real sample tablets with satisfactory results.