Pre-Formulation and Formulation Approaches for Buccal FilmsChalamaiah M* and Sharma PK
Food and Drug Toxicology Research Centre, National Institute of Nutrition (ICMR), Tarnaka, Hyderabad, India
- *Corresponding Author:
- Chalamaiah M
Food and Drug Toxicology Research Centre, National Institute of Nutrition (ICMR)
Tarnaka, Hyderabad-500604, India
E-mail: [email protected]
Received date: August 18, 2016; Accepted date: September 02, 2016; Published date: September 10, 2016
Citation: Chalamaiah M, Sharma PK (2016) Pre-Formulation and Formulation Approaches for Buccal Films. J Bioequiv Availab 8:246-248. doi: 10.4172/jbb.1000303
Copyright: © 2016 Chalamaiah M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many potential active pharmaceutical ingredients (APIs), which are drugs of abuse, or as recreational drugs, and which have narrow therapeutic index causing hundreds of deaths in recent years can be casted into buccal films. Many drugs which are lipophilic, and which can easily penetrate the blood–brain barrier can be of choice for buccal delivery. The bio-adhesive film for buccal delivery has advantage of the control delivery and has higher permeability, and lower reservoir capacity, of the epithelium. A simple system, consisting of a drug-loaded bio-adhesive coated onto an impermeable backing layer, can be easily envisaged.