Preimplantation Genetic Screening in the age of 23-chromosome evaluation Why FISH is no longer an acceptable technology?
|Paul R. Brezina1* and William G. Kearns2|
|1Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Phipps 264, 600 N. Wolfe Street, 10751 Falls Road, Suite #280, Baltimore, MD 21287|
|2Johns Hopkins Medical Institutions, Department of Gynecology and Obstetrics, Baltimore, MD, Center for Preimplantation Genetics, LabCorp. Rockville. MD 20850|
|*Corresponding Author :||Dr. Paul R. Brezina, MD, MBA
Johns Hopkins University School of Medicine
Department of Gynecology and Obstetrics
Division of Reproductive Endocrinology and Infertility
Phipps 264, 600 N. Wolfe Street, 10751
Falls Road, Suite #280, Baltimore, MD 21287
E-mail: [email protected]
|Received September 09, 2011; Accepted November 09, 2011; Published November 30, 2011|
|Citation: Brezina PR, Kearns WG (2011) Preimplantation Genetic Screening in the Age of 23-Chromosome Evaluation Why FISH is no Longer an Acceptable Technology? J Fertiliz In Vitro 1:e103. doi:|
|Copyright: © 2011 Brezina PR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Preimplantation Genetic Screening (PGS) has been used for some time with fluorescence in situ hybridization (FISH) technology with marginal success. Newer modalities capable of evaluating all 23 pairs of chromosomes are now available for PGS and are superior to PGS with FISH.